Document Detail


The evaluation of two new hyaluronan hydrogels as nasal dressing in the rabbit maxillary sinus.
MedLine Citation:
PMID:  22182701     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The postoperative scaring, ostial stenosis, and adhesions after functional endoscopic sinus surgery for chronic rhinosinusitis remains a majorproblem. This study was designed to evaluate two new hyaluronan (HA) hydrogels for neo-ostium antistenosis and promoting wound healing in a rabbitmaxillary sinus model.METHODS: The anterior wall of the maxillary sinus of 48 rabbits was removed to create a 4-mm circumferential wound both on the nasal and on the sinus sides. A rapid-gelling HA hydrogel or preformed HA hydrogel was filled randomly into the right or left sinus, while the opposite sinus served as blank control or was treated with Merogel (Medtronic Xomed Surgical Products, Jacksonville, FL) as control. The neo-ostium diameter and histological scores were evaluatedand analyzed postoperatively.RESULTS: The neo-ostium diameter in the rapid-gelling HA hydrogel-treated side was significantly larger than that in the blank control side with a meandifference of 1.46 +/- 0.99 mm (p = 0.03), 1.30+/- 0.61 mm (p = 0.0087), and 1.60+/-0.25 mm (p = 0.00015) at 2, 3, and 4 weeks, respectively; the neo-ostium diameter in the preformed HA hydrogel-treated side at 2 weeks was significantly larger than that in the blank control side or Merogel control side with a mean difference of 1.46 +/-0.76 mm (p = 0.002) or 0.54+/- 0.36 mm (p=0.007), respectively. The preformed HA hydrogel-treated side showed better histology scores at 2 weeks in heterophils, fibrosis, and osteogenesis than the blank control, and the chronic inflammation (lymphocyte/plasmacyte infiltration) was not prevalent.CONCLUSION: During the postoperative follow-up period both of the two HA hydrogels significantly prevented neo-ostium stenosis and the preformed HAhydrogel promoted wound healing.
Authors:
Q Chen; G Sun; Y Wang; W Zhong; Xz Shu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-16
Journal Detail:
Title:  American journal of rhinology & allergy     Volume:  -     ISSN:  1945-8932     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101490775     Medline TA:  Am J Rhinol Allergy     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dynein Dysfunction Disrupts Intracellular Vesicle Trafficking Bidirectionally and Perturbs Synaptic ...
Next Document:  Polyfluoroalkyl compounds in Texas children from birth through 12 years of age.