Document Detail


An evaluation of the tumour affinity of the radioactive cobalt chelate of tallysomycin S10b in lymphoma-bearing mice.
MedLine Citation:
PMID:  1724794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The tumour affinity of the radioactive cobalt chelate of tallysomycin S10b (Tlm S10b), a promising structural analogue of Bleomycin, was assessed using a mouse lymphoma model. The highest concentrations (%dose/gram tissue) were observed in the kidneys, followed by the tumour (4.1%/g 1 h p.i.) at 1 h, 4 h and 48 h. The tumour had the highest concentration among all tissues at 24 h. The biodistribution profile of 60Co-Tlm S10b was distinctly different from that obtained with 60CoCl2, demonstrating the in vivo stability of the chelate. More than half of the chelate (56.8% of the injected dose) was excreted in the urine at 1 h. The highest tumour/non-tumour ratios were obtained for blood (41.3, 4 h), bone (30.5, 4 h) and muscle (29.2, 48 h). Scintigraphy at 24 h, using 57Co-Tlm S10b, showed the tumour, liver, kidney and bladder clearly. The similarities and differences exhibited by Co-Tlm S10b with reference to the literature on cobalt chelates of Bleomycin and naturally occurring tallysomycin (A + B) are discussed.
Authors:
R Veerapandian; V M Sivaramakrishnan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuklearmedizin. Nuclear medicine     Volume:  30     ISSN:  0029-5566     ISO Abbreviation:  Nuklearmedizin     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-04-22     Completed Date:  1992-04-22     Revised Date:  2007-01-12    
Medline Journal Info:
Nlm Unique ID:  7609387     Medline TA:  Nuklearmedizin     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  189-92     Citation Subset:  IM    
Affiliation:
Isotope Division, Cancer Institute, Adyar, Madras, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bleomycin / diagnostic use*,  pharmacokinetics
Lymphoma / metabolism,  radionuclide imaging*
Male
Mice
Tissue Distribution
Chemical
Reg. No./Substance:
11056-06-7/Bleomycin; 67995-68-0/tallysomycin

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