Document Detail

An evaluation of thrombophilia screening in an urban tertiary care medical center: A "real world" experience.
MedLine Citation:
PMID:  16753592     Owner:  NLM     Status:  MEDLINE    
To evaluate the utilization of thrombophilia screening at a large urban academic tertiary care center, we retrospectively examined the indications, appropriateness, and results of 200 consecutive thrombophilia panels. Of the panels, 103 (51.5%) were ordered for venous thromboembolism; 124 (62.0%) were ordered during acute thrombotic episodes, and at least 40 (20.0%) had abnormal protein C and S results, of which 25 (63%) were attributable to anticoagulation and the remainder to pregnancy. Of the 200 panels, 46 (23.0%) had a significant abnormality; the most common abnormal result was a lupus anticoagulant, occurring in 23 cases (11.3%). Thrombophilia screening seems to be overutilized in our population, especially considering that the majority of tests are ordered during suboptimal conditions, eg, acute thrombosis, pregnancy, or anticoagulation. At present, outside the research setting, thrombophilia panels should be reserved for special circumstances, targeted to factors for which there would be a specific clinical impact, and performed in the absence of confounding clinical variables.
Jonathan Somma; Ira I Sussman; Jacob H Rand
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  126     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-06     Completed Date:  2006-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  120-7     Citation Subset:  AIM; IM    
Department of Pathology, Montefiore Medical Center, Bronx, NY 10467, USA.
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MeSH Terms
Aged, 80 and over
Blood Coagulation Tests / utilization*
Child, Preschool
Hospitals, Urban / statistics & numerical data*
Mass Screening / methods*
Middle Aged
New York City / epidemiology
Retrospective Studies
Thromboembolism / diagnosis,  etiology
Thrombophilia / complications,  diagnosis*,  epidemiology
Venous Thrombosis / diagnosis,  etiology

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