| Evaluation of paraoxonase 1 arylesterase activity and lipid peroxide levels in patients with type 1 diabetes. | |
| | |
MedLine Citation:
|
PMID: 22157813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: Poor metabolic control of type 1 diabetes is one of the most important factors accelerating the development of late diabetic complications. Several other factors that might contribute to this process are currently being investigated. Low paraoxonase 1 (PON1) activity and high lipid peroxide (LPO) levels contribute to endothelial damage, but it remains unclear whether they are critical for the development of late diabetic complications. OBJECTIVES: The aim of the study was to evaluate PON1 arylesterase activity and LPO levels in patients with type 1 diabetes and to investigate whether these parameters are associated with metabolic control and late complications. Moreover, we aimed to establish whether PON1 activity and LPO levels differ between women and men with type 1 diabetes. PATIENTS AND METHODS: The study involved 80 patients with type 1 diabetes and 24 healthy subjects. PON1 activity was measured by a spectrophotometric method. LPO levels were measured by a commercial assay kit. RESULTS: Diabetic patients had lower PON1 activity and higher LPO levels than healthy people. We observed a negative correlation between PON1 activity and LPO levels in diabetic patients. There was no association between PON1 activity or LPO levels and metabolic parameters or late diabetic complications. There was a positive correlation between LPO levels and the body mass index (BMI) in women with type 1 diabetes. CONCLUSIONS: Our study showed that low PON1 activity and high LPO levels are not the most critical factors involved in late diabetic complications in type 1 diabetes. Increased LPO levels in women with type 1 diabetes may result from enhanced lipogenesis in this subgroup compared with diabetic men. |
| | |
Authors:
|
Małgorzata Wegner; Maria Pioruńska-Stolzmann; Aleksandra Araszkiewicz; Dorota Zozulińska-Ziółkiewicz; Bogna Wierusz-Wysocka |
Related Documents
:
|
16924583 - Antihyperglycemic effect of aporphines and their derivatives in normal and diabetic rats. 11593763 - Activation of adenosine a1 receptors by drugs to lower plasma glucose in streptozotocin... 17086933 - Insulin resistance and ppar insulin sensitizers. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Polskie Archiwum Medycyny Wewnętrznej Volume: 121 ISSN: 1897-9483 ISO Abbreviation: Pol. Arch. Med. Wewn. Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2012-01-02 Completed Date: 2012-04-23 Revised Date: 2012-05-07 |
Medline Journal Info:
|
Nlm Unique ID: 0401225 Medline TA: Pol Arch Med Wewn Country: Poland |
Other Details:
|
Languages: eng Pagination: 448-54 Citation Subset: IM |
Affiliation:
|
Department of General Chemistry, Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, Poznań, Poland. malgoweg@ump.edu.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aryldialkylphosphatase / metabolism* Diabetes Mellitus, Type 1 / enzymology, metabolism* Female Humans Lipid Peroxides / metabolism* Male Oxidative Stress / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Lipid Peroxides; EC 3.1.8.1/Aryldialkylphosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthetic, multi-layer, self-oscillating vocal fold model fabrication.
Next Document: The tudor domain protein Kumo is required to assemble the nuage and to generate germline piRNAs in D...