Document Detail


The evaluation of neuroprotective efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats.
MedLine Citation:
PMID:  17685413     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neuroprotective effects of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with cyclosarin were studied. The cyclosarin-induced neurotoxicity was monitored using a functional observational battery at 24 h and 7 days following cyclosarin challenge. The results indicate that the oxime HI-6 combined with atropine seems to be the most effective antidote for a decrease in cyclosarin-induced neurotoxicity. Both newly developed oximes (K074, K075) as well as obidoxime are also able to counteract cyclosarin-induced acute neurotoxicity, but their neuroprotective potency is significantly lower compared with the oxime HI-6. Therefore, the oxime HI-6 is still the most suitable oxime for the antidotal treatment of acute poisonings with cyclosarin due to its neuroprotective as well as reactivating efficacy.
Authors:
Jiri Kassa; Jana Karasova; Libor Vasina
Related Documents :
25494283 - Influenza vaccination of pregnant women and protection of their infants.
1296793 - Accuracy of asthma death statistics in australia.
3976613 - Neonatal characteristics of maltreated infants and children.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  27     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-10-30     Completed Date:  2007-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  621-30     Citation Subset:  IM    
Affiliation:
Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic. kassa@pmfhk.cz
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylcholinesterase / metabolism
Animals
Antidotes / pharmacology*,  therapeutic use
Atropine / pharmacology*,  therapeutic use
Autonomic Nervous System / drug effects
Butanes / pharmacology
Cholinesterase Reactivators / pharmacology*,  therapeutic use
Disease Models, Animal
Male
Motor Activity / drug effects
Neuroprotective Agents / pharmacology*,  therapeutic use
Neurotoxicity Syndromes / enzymology,  etiology,  physiopathology,  prevention & control*
Obidoxime Chloride / pharmacology
Organophosphorus Compounds / poisoning
Oximes / pharmacology*,  therapeutic use
Pyridinium Compounds / pharmacology
Rats
Rats, Wistar
Sensation / drug effects
Time Factors
Chemical
Reg. No./Substance:
0/1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide; 0/Antidotes; 0/Butanes; 0/Cholinesterase Reactivators; 0/K075 compound; 0/Neuroprotective Agents; 0/Organophosphorus Compounds; 0/Oximes; 0/Pyridinium Compounds; 114-90-9/Obidoxime Chloride; 329-99-7/cyclohexyl methylphosphonofluoridate; 34433-31-3/HI 6; 51-55-8/Atropine; EC 3.1.1.7/Acetylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mechanisms of DNA breaks induction in vivo by 5-azacytidine: paths of micronucleus induction by azaC...
Next Document:  Quantification and correction of bias in tagging SNPs caused by insufficient sample size and marker ...