Document Detail

An evaluation of a kinetic acid phosphatase method.
MedLine Citation:
PMID:  868805     Owner:  NLM     Status:  MEDLINE    
The authors have evaluated a new kinetic acid phosphatase method in which the substrate is alpha-naphthyl phosphate. The original claim that this substrate was highly specific for the prostatic isozyme has been strongly challenged. Therefore, large numbers of patients in the following groupings were included in the evaluation: 52 urology clinic patients, 17 patients with uremia, 11 patients with multiple myeloma and 231 patients who had undergone prostatic biopsies. Two hundred seventy of these patients were found to be free of prostatic cancer. Of these, seven had acid phosphatase values above the upper limit of normal. Five of these seven patients had diagnoses of fibromuscular glandular hyperplasia. One was a woman who had multiple myeloma, and one was a uremic patient. Fifteen of 17 patients who had metastatic cancer of the prostate had elevated acid phosphatase activities, whereas one of 24 patients who had cancer of the prostate but no evidence of metastases had an elevated value.
L M Shaw; W Brummund; R J Dorio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  68     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-07-29     Completed Date:  1977-07-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-62     Citation Subset:  AIM; IM    
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MeSH Terms
Acid Phosphatase / analysis*
Clinical Enzyme Tests / methods*
Middle Aged
Neoplasm Metastasis
Organophosphorus Compounds
Prospective Studies
Prostate / enzymology
Prostatic Diseases / enzymology
Prostatic Neoplasms / diagnosis
Retrospective Studies
Reg. No./Substance:
0/Naphthalenes; 0/Organophosphorus Compounds; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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