Document Detail

An evaluation of the irritancy potential of povidone iodine solutions: comparison of subjective and objective assessment techniques.
MedLine Citation:
PMID:  1451313     Owner:  NLM     Status:  MEDLINE    
A double-blind study has been carried out in 12 normal volunteer subjects in order to determine the relative irritancy of povidone-iodine solutions. Aqueous solutions of 10% povidone-iodine (PI), standardized 10% povidone-iodine (SPI) and reformulated standardized 10% povidone-iodine (RSPI) were applied to the backs and occluded using aluminium chambers. At 1, 2, 3, 4, 5, 6, and 8 hours, chambers were removed and the degree of cutaneous irritancy assessed. As well as subjective assessment of erythema, objective measurement of skin colour was performed using an erythema meter. In addition, laser Doppler blood-flow measurements have been carried out. The results show a rapid increase in cutaneous irritancy as evidenced by an increase in visual scores of erythema, increased erythema meter readings and increased cutaneous blood-flow. The increase was greatest for SPI treated sites for all three methods. Statistically these differences were significant at P < 0.05. Thus in this controlled study it has been possible to discriminate between the similar formulations in terms of their cutaneous irritancy.
P J Dykes; R Marks
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  17     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1993-01-06     Completed Date:  1993-01-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  246-9     Citation Subset:  IM    
Department of Dermatology, University of Wales College of Medicine, Cardiff.
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MeSH Terms
Double-Blind Method
Evaluation Studies as Topic
Irritants / adverse effects*
Middle Aged
Povidone-Iodine / adverse effects*
Skin / drug effects*
Reg. No./Substance:
0/Irritants; 25655-41-8/Povidone-Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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