Document Detail


An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium.
MedLine Citation:
PMID:  6707197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since calcium solubility is a prerequisite to calcium absorption, and since solubility of calcium is highly pH-dependent, it has been generally assumed that gastric acid secretion and gastric acidity play an important role in the intestinal absorption of calcium from ingested food or calcium salts such as CaCO3. To evaluate this hypothesis, we developed a method wherein net gastrointestinal absorption of calcium can be measured after ingestion of a single meal. A large dose of cimetidine, which markedly reduced gastric acid secretion, had no effect on calcium absorption in normal subjects, and an achlorhydric patient with pernicious anemia absorbed calcium normally. This was true regardless of the major source of dietary calcium (i.e., milk, insoluble calcium carbonate, or soluble calcium citrate). Moreover, calcium absorption after CaCO3 ingestion was the same when intragastric contents were maintained at pH 7.4 (by in vivo titration) as when intragastric pH was 3.0. On the basis of these results, we conclude that gastric acid secretion and gastric acidity do not normally play a role in the absorption of dietary calcium. Other possible mechanisms by which the gastrointestinal tract might solubilize ingested calcium complexes and salts are discussed.
Authors:
G W Bo-Linn; G R Davis; D J Buddrus; S G Morawski; C Santa Ana; J S Fordtran
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  73     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-05-02     Completed Date:  1984-05-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  640-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Achlorhydria / complications,  metabolism
Adult
Anemia, Pernicious / complications
Calcium Carbonate / metabolism
Calcium, Dietary / metabolism*
Cimetidine / diagnostic use
Citrates / metabolism
Citric Acid
Female
Gastric Acid / secretion*
Humans
Hydrogen-Ion Concentration
Intestinal Absorption*
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
AM-01204/AM/NIADDK NIH HHS; AM-17328/AM/NIADDK NIH HHS; AM-26794/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Calcium, Dietary; 0/Citrates; 471-34-1/Calcium Carbonate; 51481-61-9/Cimetidine; 77-92-9/Citric Acid
Comments/Corrections

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