Document Detail


An evaluation of the immunochemical measurement of prostatic acid phosphatase and prostatic specific antigen in carcinoma of the prostate.
MedLine Citation:
PMID:  2420600     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum prostatic specific antigen (PSA) and prostatic acid phosphatase (PAP) were evaluated with double monoclonal radioimmunoassays. In 250 patients with prostatic cancer the normal limits were as follows: PSA 0.1-2.7 ng/ml, and PAP 1.09 +/- 0.45 ng/ml (mean +/- SD). In 91 untreated patients with non-metastatic tumours, 42.8% had PSA greater than 10 ng/ml and 18.6% had PAP greater than 2 ng/ml. In 60 untreated patients with metastatic disease PSA was greater than 10 ng/ml in 91.7%; PAP was greater than 2 ng/ml in 65%. In prolonged remission PSA was generally less than 5 ng/ml and PAP less than 2 ng/ml. Longitudinal studies of 2-4 years showed the independence of these markers and a higher correlation of changes in the PSA level and clinical status than given by parallel PAP measurements. In non-metastatic disease, PSA greater than 10 ng/ml at presentation, with or without a coincidentally raised PAP, carried an increased risk of progression within 2 years.
Authors:
J K Siddall; E H Cooper; D W Newling; M R Robinson; P Whelan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European urology     Volume:  12     ISSN:  0302-2838     ISO Abbreviation:  Eur. Urol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-05-14     Completed Date:  1986-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512719     Medline TA:  Eur Urol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  123-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acid Phosphatase / blood,  metabolism*
Aged
Antibodies, Monoclonal / analysis
Antigens, Neoplasm / analysis*
Humans
Male
Prognosis
Prostate-Specific Antigen
Prostatic Neoplasms / enzymology,  immunology,  metabolism*,  therapy
Radioimmunoassay
Reference Values
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Neoplasm; EC 3.1.3.2/Acid Phosphatase; EC 3.4.21.77/Prostate-Specific Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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