Document Detail


An evaluation of hemolymph cholinesterase activities in the tropical scallop, Euvola (Pecten) ziczac, for the rapid assessment of pesticide exposure.
MedLine Citation:
PMID:  12474960     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of sequential measurements of hemolymph cholinesterase activities as a non-invasive biomarker of seasonal organophosphate/carbamate exposure was investigated for the tropical scallop, Euvola (Pecten) ziczac. Overall activities of both acetylcholinesterase and butyrylcholinesterase were relatively high compared to studies with bivalve tissues. Acute in vivo experiments showed inhibition of hemolymph acetylcholinesterase activity at concentrations of the organophosphate insecticide chlorpyrifos of 0.1, 1 and 10 ng l(-1). Monthly sampling of hemolymph from scallops at two sites in Bermuda over a 15 month period showed seasonal acetylcholinesterase and butyrylcholinesterase inhibition. Direct and indirect evidence suggests that this inhibition did not relate to biochemical or physiological changes associated with gonad maturation and spawning, but rather reflected diffuse contamination of the marine environment by cholinesterase inhibitors or increased bioavailability of such inhibitors at these times. Repetitive sampling of scallop hemolymph for cholinesterase activities represents a rapid, sensitive and non-invasive method for assessing seasonal, sublethal pesticide exposure in these commercially important bivalves and suggests a wider use in marine pollution monitoring.
Authors:
Richard Owen; Lucy Buxton; Samia Sarkis; Megan Toaspern; Anthony Knap; Michael Depledge
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Marine pollution bulletin     Volume:  44     ISSN:  0025-326X     ISO Abbreviation:  Mar. Pollut. Bull.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-12-11     Completed Date:  2003-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0260231     Medline TA:  Mar Pollut Bull     Country:  England    
Other Details:
Languages:  eng     Pagination:  1010-7     Citation Subset:  IM    
Affiliation:
Bermuda Biological Station for Research, Ferry Reach, St Georges GE01, Bermuda. rowen@bbsr.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Assay / methods
Biological Availability
Biological Markers / analysis
Cholinesterases / pharmacology*
Environmental Monitoring / methods*
Hemolymph / enzymology
Mollusca*
Pesticides / adverse effects*,  analysis
Water Pollutants, Chemical / adverse effects*,  analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Pesticides; 0/Water Pollutants, Chemical; EC 3.1.1.8/Cholinesterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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