Document Detail

The evaluation of haemodynamics in cirrhotic patients with spectral CT.
MedLine Citation:
PMID:  23881800     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate haemodynamics in cirrhotic patients with portal hypertension using spectral CT imaging.
METHODS: 118 cirrhotic patients with portal hypertension were included in the study group (further divided into Child-Pugh A, B and C subgroups). The control group consisted of 21 subjects with normal liver functionality. All subjects underwent three-phase spectral CT scans. Material decomposition images with water and iodine as basis material pairs were reconstructed. The iodine concentrations for the hepatic parenchyma in both arterial and portal venous phases were measured. The arterial iodine fraction (AIF) was obtained by dividing the iodine concentration in the hepatic arterial phase by that in the portal venous phase. AIF values from the study and control groups were compared using analysis of variance and between subgroups using a post-hoc test with Bonferroni correction, with a statistical significance of p<0.05.
RESULTS: The AIF was 0.25±0.05 in the control group, and 0.29±0.10, 0.37±0.12 and 0.43±0.14 in the study group with Child-Pugh Grades A, B and C, respectively. The difference in AIF between the control and study groups was statistically significant. The differences were statistically significant between the subgroups with multiple comparisons except between the control group and the Child-Pugh A group (p=0.685).
CONCLUSION: AIF measured in spectral CT could be used to evaluate the liver haemodynamics of cirrhotic patients.
ADVANCES IN KNOWLEDGE: The AIF, provided by spectral CT, could be used as a new parameter to observe liver haemodynamics.
L-Q Zhao; W He; B Yan; H-Y Wang; J Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of radiology     Volume:  86     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-24     Completed Date:  2013-09-30     Revised Date:  2014-08-03    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  20130228     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Contrast Media / diagnostic use
Hypertension, Portal / physiopathology,  radiography*
Iodine / analysis
Iohexol / diagnostic use
Liver / physiopathology,  radiography
Liver Cirrhosis / physiopathology,  radiography*
Middle Aged
Portal Vein / physiopathology,  radiography
Retrospective Studies
Tomography, X-Ray Computed / methods*
Reg. No./Substance:
0/Contrast Media; 4419T9MX03/Iohexol; 9679TC07X4/Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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