| An evaluation of gastric emptying times in pregnancy and the puerperium. | |
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MedLine Citation:
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PMID: 8434749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a controlled study, gastric emptying was measured during the three trimesters of pregnancy and after delivery, using an indirect paracetamol absorption technique. The peak plasma paracetamol concentration, time to reach the peak, and the area under the plasma paracetamol concentration-time curve, were determined. As compared to nonpregnant controls, there were no significant differences in the gastric emptying times of women in the three trimesters of pregnancy and of mothers from 18 h after delivery onwards. Gastric emptying was significantly delayed in mothers within 2 h after delivery (p < 0.01); median (range) values of peak paracetamol concentration, time to reach the peak and the area under the paracetamol concentration-time curve for this group were 12.5 (0.2-30.5) mg.l-1, 120 (30-120) min and 3.8 (0.1-16.6) mg.l-1 x h respectively, and 20.8 (8.6-64.5) mg.l-1, 40 (10-120) min and 13.5 (5.5-28.8) mg.l-1 x h respectively, for the nonpregnant control group (p < 0.01). Repeated measurements of gastric emptying in these women on the second postpartum day showed no significant delay. |
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Authors:
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E M Whitehead; M Smith; Y Dean; G O'Sullivan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anaesthesia Volume: 48 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 1993 Jan |
Date Detail:
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Created Date: 1993-03-15 Completed Date: 1993-03-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 53-7 Citation Subset: AIM; IM |
Affiliation:
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St Thomas' Hospital, London. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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blood Adult Female Gastric Emptying / physiology* Humans Pneumonia, Aspiration Postpartum Period / physiology Pregnancy / physiology* Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy Trimester, Third Risk Factors |
| Chemical | |
Reg. No./Substance:
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103-90-2/Acetaminophen |
| Comments/Corrections | |
Comment In:
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Anaesthesia. 1993 Sep;48(9):821-2
[PMID:
8105714
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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