Document Detail


An evaluation of gastric emptying times in pregnancy and the puerperium.
MedLine Citation:
PMID:  8434749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a controlled study, gastric emptying was measured during the three trimesters of pregnancy and after delivery, using an indirect paracetamol absorption technique. The peak plasma paracetamol concentration, time to reach the peak, and the area under the plasma paracetamol concentration-time curve, were determined. As compared to nonpregnant controls, there were no significant differences in the gastric emptying times of women in the three trimesters of pregnancy and of mothers from 18 h after delivery onwards. Gastric emptying was significantly delayed in mothers within 2 h after delivery (p < 0.01); median (range) values of peak paracetamol concentration, time to reach the peak and the area under the paracetamol concentration-time curve for this group were 12.5 (0.2-30.5) mg.l-1, 120 (30-120) min and 3.8 (0.1-16.6) mg.l-1 x h respectively, and 20.8 (8.6-64.5) mg.l-1, 40 (10-120) min and 13.5 (5.5-28.8) mg.l-1 x h respectively, for the nonpregnant control group (p < 0.01). Repeated measurements of gastric emptying in these women on the second postpartum day showed no significant delay.
Authors:
E M Whitehead; M Smith; Y Dean; G O'Sullivan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia     Volume:  48     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-03-15     Completed Date:  1993-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  53-7     Citation Subset:  AIM; IM    
Affiliation:
St Thomas' Hospital, London.
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / blood
Adult
Female
Gastric Emptying / physiology*
Humans
Pneumonia, Aspiration
Postpartum Period / physiology
Pregnancy / physiology*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Risk Factors
Chemical
Reg. No./Substance:
103-90-2/Acetaminophen
Comments/Corrections
Comment In:
Anaesthesia. 1993 Sep;48(9):821-2   [PMID:  8105714 ]

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