Document Detail

An evaluation of the efficacy of the toe brachial index measuring vascular involvement in systemic sclerosis and other connective tissue diseases.
MedLine Citation:
PMID:  19796558     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The ankle and toe brachial indices (ABI and TBI) are calculated as the ankle and toe systolic blood pressures divided by the highest brachial systolic pressure, respectively. We sought to evaluate the efficacy of ABI and TBI as an objective, non-invasive assessment of vascular involvement in patients with systemic sclerosis (SSc) and to investigate the clinical significance of TBI in SSc. METHODS: ABI and TBI were measured using an oscillometric method in 136 outpatients, including 77 with SSc, 29 with systemic lupus erythematosus (SLE), 16 with primary Sj??gren's syndrome (SjS), and 14 with dermatomyositis (DM). We also analyzed 21 healthy controls. RESULTS: The mean ABI and frequency of reduced ABI values (%1.0) did not differ significantly between disease groups. TBI values in patients with SSc and lSSc were significantly lower than in those with SjS and DM, respectively (p%0.01). Patients with SSc and lSSc had significantly lower TBI values than healthy controls (p%0.05). Reduced TBI values (%0.6) were significantly more common in patients with SSc, including both dSSc and lSSc, than in those with SLE (p%0.05). Similarly, the frequency of decreased TBI was higher in patients with SSc and dSSc than in those with SjS or healthy controls (p%0.05). Skin ulcers (p=0.041) or overlap with rheumatoid arthritis (p=0.018) were associated with reduced TBI values by logistic regression analysis. CONCLUSION: The TBI value is a useful, non-invasive tool to evaluate vascular involvement in SSc.
Y Muro; K Sugiura; Y Morita; Y Tomita
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  27     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-10-02     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  26-31     Citation Subset:  IM    
Division of Connective Tissue Disease and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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MeSH Terms
Aged, 80 and over
Ankle Brachial Index / methods*
Blood Pressure / physiology
Connective Tissue Diseases / physiopathology*
Middle Aged
Predictive Value of Tests
Scleroderma, Systemic / physiopathology*
Toes / blood supply*
Young Adult

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