Document Detail


An evaluation of the efficacy and safety of doxazosin in hypertension associated with renal dysfunction. The Japanese Doxazosin Study Group.
MedLine Citation:
PMID:  1824664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Doxazosin was administered once daily to 26 patients with renal hypertension or hypertension associated with renal dysfunction. Doxazosin produced a significant reduction in blood pressure that was stable throughout the treatment period. A significant change was not observed in heart rate. Blood pressure was "markedly decreased" or "decreased" in 80% of patients receiving doxazosin monotherapy, 78.6% of patients receiving combined therapy, and 79.2% of all the patients. The cumulative efficacy ratio according to final daily dose was 62.5% with 1 to 4 mg/day and 75.0% to 79.2% with 8 to 16 mg/day. Side effects were observed in three patients (12.0%), none of them severe, and all side effects disappeared with continued administration of doxazosin. Abnormal laboratory values in six items were observed in four patients. Serum creatinine and blood urea nitrogen values, which were regarded as renal function parameters, did not show significant changes, and no negative influence was observed with respect to doxazosin therapy. Overall clinical usefulness was considered "very useful" or "useful" in 80% of patients receiving doxazosin monotherapy, 78.6% of patients receiving combination therapy, and 79.2% of all patients. In conclusion, once-daily administration of doxazosin was considered a useful antihypertensive therapy for renal hypertension and hypertension associated with renal dysfunction.
Authors:
Y Miura; M Watanabe; K Yoshinaga
Related Documents :
7089494 - Clinical experience of long-term treatment with minoxidil in severe arterial hypertension.
127594 - Factors predisposing to postural hypotensive symptoms in the treatment of high blood pr...
21175084 - Delayed gastric emptying in patients with prader willi syndrome.
16572194 - Management in general practice of hypertensive patients poorly controlled with a fixed-...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  American heart journal     Volume:  121     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-02-04     Completed Date:  1991-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  381-8     Citation Subset:  AIM; IM    
Affiliation:
Second Department of Internal Medicine, Tohoku University, School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antihypertensive Agents / administration & dosage,  therapeutic use*
Doxazosin
Drug Therapy, Combination
Female
Humans
Hypertension, Renal / drug therapy*
Male
Middle Aged
Prazosin / administration & dosage,  analogs & derivatives*,  therapeutic use
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 19216-56-9/Prazosin; 74191-85-8/Doxazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A multicenter study of doxazosin in the treatment of patients with mild or moderate essential hypert...
Next Document:  The effect of doxazosin on platelet aggregation in normotensive subjects and patients with hypertens...