| An evaluation of the efficacy of olmesartan medoxomil in Black patients with hypertension. | |
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MedLine Citation:
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PMID: 20409982 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Blacks appear to have a more modest blood pressure (BP) response to angiotensin receptor blocker (ARB) monotherapy than non-Blacks. This post-hoc analysis compared the BP-lowering efficacy of olmesartan medoxomil (OM), losartan potassium (LOS), and valsartan (VAL) in Black versus non-Black participants in a randomized, forced-titration study. Patients were randomized to OM 20, LOS 50, and VAL 80mg/day or placebo for 4 weeks and uptitrated to 40, 100, and 320mg/day doses, respectively, by study end. The primary end point was the mean change from baseline in diastolic BP (DBP) at week 8. All treatments produced significant reductions in mean DBP and systolic BP (SBP) in Blacks (n=150; P < .001). BP <140/90mm Hg was achieved in 35.0%, 15.6%, 29.7%, and 5.0% of Blacks receiving OM, LOS, VAL, and placebo, respectively, and in 41.0%, 21.1%, 28.8%, and 14.5% of non-Blacks receiving OM, LOS, VAL, and placebo, respectively, after 8 weeks. BP-lowering efficacy of the three agents was similar at 3 months. OM had the greatest early efficacy, with numerically greater mean reductions in DBP and SBP, and a higher proportion of Black and non-Black patients achieving goal BP of 140/90mm Hg at week 8. |
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Authors:
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Thomas D Giles; Suzanne Oparil; Antonia Wang; Robert Dubiel |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American Society of Hypertension : JASH Volume: 3 ISSN: 1933-1711 ISO Abbreviation: J Am Soc Hypertens Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2010-04-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101312518 Medline TA: J Am Soc Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 395-402 Citation Subset: - |
Affiliation:
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Tulane University School of Medicine, New Orleans, Louisiana, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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