Document Detail

The evaluation of effects of demographic features, biochemical parameters, and cytokines on clinical outcomes in patients with acute renal failure.
MedLine Citation:
PMID:  17497476     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the effects of cytokines, biochemical parameters and demographic features on clinical outcomes of acute renal failure (ARF). PATIENTS AND METHODS: 59 patients with acute renal failure (28 men, 31 women) were enrolled to the study. Cytokines, biochemical parameters, and complete blood count were measured. Patients were divided into two groups: as survivors (group 1, n = 46) and nonsurvivors (group 2, n = 13). RESULTS: Mean age of patients were 52.3 +/- 17.9 years. 46 patients survived (77.9%) and 13 patients died (22.1%). There was a statistically significant relationship between IL-2R, IL-6, and TNF-alpha levels and mortality rates (p = 0.004, p = 0.016, p = 0.020, respectively) and between TC levels and mortality rates (p = 0.041). In multivariable logistic regression analysis, the effects of proinflammatory cytokines (IL-1beta, IL-2R, IL-6, TNFalpha, CRP, and ESR) on the clinical outcomes in ARF was observed to be statistically significant (r = 0.341, p = 0.005). CONCLUSION: We realized that in totally demographic features (male gender, advanced age, poor nutritional status), biochemical parameters (TC, albumin, and hemoglobin) and cytokine levels (IL-2R, IL-6, TNF-alpha), CRP and ESR may be predictive factors for mortality in patients with ARF.
Ali Kemal Kadiroglu; Dede Sit; A Engin Atay; Hasan Kayabasi; Abdullah Altintas; M Emin Yilmaz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  29     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-14     Completed Date:  2007-08-14     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  503-8     Citation Subset:  IM    
Department of Internal Medicine, Medicine Faculty of Dicle University, Diyarbakir, Turkey.
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MeSH Terms
C-Reactive Protein / analysis
Cytokines / blood*
Interleukin-2 / blood
Interleukin-6 / blood
Kidney Failure, Acute / blood*,  mortality*
Logistic Models
Middle Aged
Nutritional Status
Treatment Outcome
Tumor Necrosis Factor-alpha / analysis
Reg. No./Substance:
0/Cytokines; 0/Interleukin-2; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein

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