Document Detail


An evaluation of cyclosporin and corticosteroids individually as adjuncts to plasma exchange in the treatment of thrombotic thrombocytopenic purpura.
MedLine Citation:
PMID:  17069579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present the results of two consecutively performed cohort studies that evaluated the clinical effects of corticosteroids or cyclosporin as an adjunct to plasma exchange (PE) for the treatment of an acute episode of thrombotic thrombocytopenic purpura (TTP). In comparing 12 corticosteroid-treated patients with eight cyclosporin-treated patients, none of the cyclosporin-treated patients suffered an exacerbation or recurrence of TTP in the first 30 d after discontinuing PE compared with 6/10 (60%) of the corticosteroid-treated patients (P = 0.042). These data suggest that cyclosporin may have advantages over corticosteroids as an adjunct to PE therapy in the initial treatment of idiopathic TTP.
Authors:
Spero R Cataland; Ming Jin; Amy K Ferketich; Melanie S Kennedy; Eric H Kraut; James N George; Haifeng M Wu
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-10-27
Journal Detail:
Title:  British journal of haematology     Volume:  136     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-15     Completed Date:  2007-03-28     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  146-9     Citation Subset:  IM    
Affiliation:
Division of Hematology/Oncology, Department of Internal Medicine, Ohio state University, Columbus, OH 43210, USA. spero.cataland@osumc.edu
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MeSH Terms
Descriptor/Qualifier:
ADAM Proteins / blood,  immunology
Adrenal Cortex Hormones / therapeutic use*
Adult
Autoantibodies / blood
Chemotherapy, Adjuvant
Cyclosporine / therapeutic use*
Female
Humans
Immunoglobulin G / blood
Immunosuppressive Agents / therapeutic use*
Male
Middle Aged
Plasma Exchange*
Prospective Studies
Purpura, Thrombotic Thrombocytopenic / drug therapy,  immunology,  therapy*
Remission Induction
Grant Support
ID/Acronym/Agency:
K08HL03279/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Autoantibodies; 0/Immunoglobulin G; 0/Immunosuppressive Agents; 59865-13-3/Cyclosporine; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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