Document Detail

An evaluation of the cost-effectiveness of omalizumab for the treatment of severe allergic asthma.
MedLine Citation:
PMID:  18445184     Owner:  NLM     Status:  MEDLINE    
Omalizumab is the first licensed anti-immunoglobulin (Ig) E antibody shown to be effective for treatment of allergic (IgE-mediated) asthma. Recent international guidelines recommend omalizumab as add-on treatment to fixed dose inhaled corticosteroid (ICS) and long-acting beta(2)-agonist (LABA) combination therapy. However, omalizumab is more expensive than other current asthma treatments and health and reimbursement authorities are increasingly demanding evidence of economic benefit to support pricing and formulary listing. The aims of this article are to (i) summarize data on the human and economic burden of severe asthma, (ii) summarize the efficacy data obtained for omalizumab in clinical trials in patients with inadequately controlled severe persistent allergic asthma despite high-dose ICS plus a LABA, and (iii) discuss the cost-effectiveness evidence published for omalizumab in this patient population. A wealth of evidence exists highlighting that the health, economic and societal burden of asthma is considerable and is highly skewed towards patients with severe asthma, particularly when asthma is inadequately controlled. Omalizumab is clinically beneficial in patients with severe persistent allergic asthma despite high-dose ICS plus a LABA, particularly in a subgroup of patients who respond to therapy. In patients who respond to therapy, the cost-effectiveness of omalizumab compares well with other biologic treatments for chronic illness.
S D Sullivan; F Turk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Allergy     Volume:  63     ISSN:  1398-9995     ISO Abbreviation:  Allergy     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-04-30     Completed Date:  2008-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  670-84     Citation Subset:  IM    
Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, WA 98195, USA.
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MeSH Terms
Anti-Asthmatic Agents / economics*,  therapeutic use
Antibodies, Monoclonal / economics*,  therapeutic use
Asthma / drug therapy*,  economics,  mortality
Clinical Trials as Topic
Cost of Illness
Cost-Benefit Analysis
Drug Costs
Immunoglobulin E / immunology
Quality of Life
Randomized Controlled Trials as Topic
Treatment Outcome
Reg. No./Substance:
0/Anti-Asthmatic Agents; 0/Antibodies, Monoclonal; 0/omalizumab; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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