| An evaluation of the ability of leucocyte depletion filters to remove components of amniotic fluid* | |
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MedLine Citation:
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PMID: 22804692 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Haemorrhage remains an important cause of maternal mortality worldwide. Cell salvage carries a theoretical risk of amniotic fluid embolus syndrome and is too expensive for use in many parts of the world. To explore cheaper options, we investigated whether a leucocyte depletion filter alone removes components of pure amniotic fluid. Amniotic fluid was collected from 10 women during elective caesarean section and passed through a LeukoGuard(®) RS filter. Pre- and post-filtration samples were compared in the laboratory. Lamellar bodies and fetal squames were almost completely removed (filtration efficacy 96.6% and 99.9%, respectively; p < 0.0001 and <0.0004), and hair was completely removed (p = 0.002). Filtration had no effect on concentrations of α-fetoprotein, tissue factor or endothelin-1, or on the presence of meconium or vernix. Additional work is required to evaluate whether cell salvage using filtration alone may be useful in maternal haemorrhage in the developing world. |
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Authors:
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J P Campbell; M J Mackenzie; S M Yentis; S R Sooranna; M R Johnson |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-17 |
Journal Detail:
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Title: Anaesthesia Volume: - ISSN: 1365-2044 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland. |
Affiliation:
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Obstetric Anaesthetic Fellow Consultant Anaesthetist Consultant Obstetrician, Chelsea and Westminster Hospital, London, UK Honorary Reader Research Scientist Professor, Imperial College, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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