| An evaluation of 75 terminations of pregnancy based on abnormal laboratory findings at first trimester CVS. | |
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MedLine Citation:
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PMID: 2225529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seventy-five selective terminations, based on abnormal laboratory findings at first-trimester CVS, were performed in 1581 consecutive pregnancies. In all cases a (semi-) direct method of cytogenetic analysis was used. The 75 abortions were analysed in number of ways. Confirmatory studies showed that three cases had to be considered as false-positive findings, and in one other case the results were inconclusive. Based on literature data, it was estimated that 41 of the 75 pregnancies would have resulted in seriously handicapped children, surviving beyond the age of 1 year, if no termination of pregnancy had taken place. Negative side-effects of the procedure include: spontaneous abortion of chromosomally normal fetuses due to the CVS procedure itself and the need for a number of secondary amniocenteses (5.1%). The advantage of DNA diagnosis in X-linked diseases is illustrated by comparing the CVS results with a previously published amniocentesis study. 75 selective terminations, based on abnormal laboratory findings at 1st trimester CVS, were performed in 1581 consecutive pregnancies. In all cases, a semidirect method of cytogenetic analysis was used. The 75 abortions were analyzed in many ways. Confirmatory studies showed that 3 cases were considered false-positive findings, and in 1 other case, the results were inconclusive. Based on literature data, it was estimated that 41.75 pregnancies would have resulted in seriously handicapped children, surviving beyond 1 year of age, if no pregnancy termination had taken place. Negative side effects of the procedure include: spontaneous abortion of chromosomally normal fetuses due to the CVS procedure itself and the need for a number of secondary amniocenteses (5.1%). The advantage of DNA diagnosis in x-linked diseases is illustrated by comparing the CVS results with a previously published amniocentesis study. |
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Authors:
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N J Leschot; H H Kanhai; C J van Asperen; H Wolf; K Boer; A C van Prooijen-Knegt; G C Christiaens; M Verjaal; E Briet |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical genetics Volume: 38 ISSN: 0009-9163 ISO Abbreviation: Clin. Genet. Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1990-12-04 Completed Date: 1990-12-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0253664 Medline TA: Clin Genet Country: DENMARK |
Other Details:
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Languages: eng Pagination: 211-7 Citation Subset: IM; J |
Affiliation:
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Department of Human Genetics, University of Amsterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Eugenic* Adult Chorionic Villi Sampling* Chromosome Aberrations / genetics* DNA / genetics Female Fragile X Syndrome / genetics Genetic Markers / genetics Genetic Testing* Hemophilia A / genetics Humans Infant, Newborn Karyotyping Life Expectancy Linkage (Genetics) / genetics Muscular Dystrophies / genetics Pregnancy Retinal Degeneration / genetics Risk Factors X Chromosome |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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