| An etiology of nephrotic syndrome in chronic interstitial nephritis (pyelonephritis); an electron microscopic study. | |
| | |
MedLine Citation:
|
PMID: 610418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Renal tissues were studied using electron microscopy (EM) and immunofluorescence microscopy (IFM) from three patients who were found to have chronic interstitial nephritis (pyelonephritis) by light microscopy (LM). By LM, 90% of the glomeruli in two patients and all glomeruli in one patient were normal. By EM, glomerular capillaries in all patients revealed generalized fusion of epithelial foot processes. In two patients, IFM for immunoglobulins, third component of complement and fibrinogen were negative. These two patients received corticosteroids for 6 to 12 weeks. In one, proteinuria markedly decreased (from 17.9 to 1.1 gm) in four weeks and in the other follow-up studies of renal histology revealed normal glomeruli and partial restoration of foot processes by LM and EM respectively. Thus, this study offers evidence for lipoid nephrosis (or minimal lesion disease) as an etiology of nephrotic syndrome in chronic interstitial nephritis (pyelonephritis). The impaired renal function in these patients is attributed to tubulo-interstitial disease rather than glomerular pathology. It remains to be determined whether the two disparate pathological conditions have coexisted or chronic interstitial nephritis had led to the appearance of lipoid nephrosis through an unidentified mechanism. |
| | |
Authors:
|
A K Mandal; J A Nordquist; S Kraikitpanitch; R D Lindeman |
Related Documents
:
|
19730428 - N-acetylcysteine infusion reduces the resistance index of renal artery in the early sta... 20847568 - Accelerated decline of gfr in diabetic nephropathy predicted by interferon release assa... 21710328 - Reproducibility of bold localization of interictal activity in patients with focal epil... 17601378 - Disease progression, response to acei/atra therapy and influence of ace gene in iga nep... 23367878 - Clinical features of eosinophilic esophagitis: ten japanese cases. 1080878 - Free rheumatoid factor in dental periapical lesions and gingivae of patients with rheum... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: The American journal of the medical sciences Volume: 274 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1977 Nov-Dec |
Date Detail:
|
Created Date: 1978-05-17 Completed Date: 1978-05-17 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 317-23 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Chronic Disease Female Humans Kidney Glomerulus / ultrastructure* Male Middle Aged Nephrosis / pathology Nephrotic Syndrome / etiology*, pathology Proteinuria / pathology Pyelonephritis / complications*, pathology Pyuria / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diagnosis and successful management of septal myocardial abscess: a complication of bacterial endoca...
Next Document: Pleural effusion: a rare manifestation of acute pulmonary blastomycosis.