Document Detail

An etiology of narcolepsy-cataplexy and a proposed cataplexy neuromechanism.
MedLine Citation:
PMID:  7287329     Owner:  NLM     Status:  MEDLINE    
Narcolepsy-cataplexy is an idiopathic sleep disorder that reflects a complex neuropathology. Surveys and physiological investigations indicate that genetic and stress factors are involved in its onset and that stress is associated with symptomatic fluctuations and exacerbations of its clinical course. This paper summarizes the literature regarding the evolution, characteristics and treatment of the disorder. A comprehensive etiology is advanced, integrating neurophysiological and psychological factors specific to narcolepsy-cataplexy with recent advances in blood pressure regulation. Moreover, a testable neuromechanism of cataplexy is proposed, based on longitudinal effects of chronic drowsiness, the strong hypnogenic effect obtained by carotid sinus stimulation, an experimental animal model of narcolepsy-cataplexy, the adaptive characteristics of baroreceptors and, finally, the interconnections between CNS sleep and blood pressure regulators of the brain stem. Through better understanding of the causes and mechanisms of narcolepsy-cataplexy, more effective treatments and preventive measures can be developed, high risk populations identified, and, perhaps, a cure found. Suggestions for future physiological and epidemiological research are made.
L Scrima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  15     ISSN:  0020-7454     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  1981  
Date Detail:
Created Date:  1981-12-21     Completed Date:  1981-12-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  69-86     Citation Subset:  IM    
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MeSH Terms
Cataplexy / drug therapy,  etiology*,  physiopathology
Narcolepsy / drug therapy,  etiology*,  physiopathology
Stress, Physiological / physiopathology

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