Document Detail

The etiology of acute recurrent pancreatitis in children: a challenge for pediatricians.
MedLine Citation:
PMID:  21499205     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: : To assess specific etiologies of acute recurrent pancreatitis at a single Italian pediatric cystic fibrosis (CF) center.
METHODS: : We studied, retrospectively, 78 young patients (39 female subjects; mean age at diagnosis, 8.8 ± 5.1 years) affected by acute recurrent episodes of pancreatitis, remained etiologically undiagnosed at first-level assessment. All patients were submitted to endoscopic retrograde cholangiopancreatography to exclude biliopancreatic malformations and tested for CF by a sweat chloride test. Most patients also were studied for the research of CFTR, PRSS1, and SPINK1 gene mutations.
RESULTS: : A high percentage of family history for chronic pancreatitis was observed (20.5%). The sweat test identified 8 subjects (10.3%) with classic CF (2 patients) or at risk for CF (6 patients). Genetic analysis showed mutations in CFTR, SPINK1, and PRSS1 genes in 39.6%, 7.1%, and 4.5% of patients, respectively. A biliopancreatic malformation was diagnosed in 15 patients (19.2%). We also observed biliary lithiasis (5 patients [6.5%]), congenital pancreatic polycystosis (2 patients), a case of dyslipidemia, and 1 patient with a posttransplantation, drug-induced pancreatitis.
CONCLUSIONS: : Recurrent pancreatitis in children has several etiologies. Genetic testing confirms the high frequency of CFTR mutations. This suggests that it is of some value to identify patients with late-onset CF and CFTR-related disorders.
Vincenzina Lucidi; Federico Alghisi; Luigi Dall'oglio; Maria Rosaria D'Apice; Lidia Monti; Paola De Angelis; Stefano Gambardella; Adriano Angioni; Giuseppe Novelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  40     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  517-21     Citation Subset:  IM    
From the *Unit of Cystic Fibrosis, and †Surgical and Endoscopic Digestive Unit, Bambino Gesù Children's Hospital, Istituto di Ricerca e Cura a Carattere Scientifico; ‡Department of Biopathology and Diagnostic Imaging, Tor Vergata University; §Department of Radiology, and ∥Laboratory of Cytogenetics and Molecular Genetics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
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