| The etiology of acute recurrent pancreatitis in children: a challenge for pediatricians. | |
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MedLine Citation:
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PMID: 21499205 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES: : To assess specific etiologies of acute recurrent pancreatitis at a single Italian pediatric cystic fibrosis (CF) center. METHODS: : We studied, retrospectively, 78 young patients (39 female subjects; mean age at diagnosis, 8.8 ± 5.1 years) affected by acute recurrent episodes of pancreatitis, remained etiologically undiagnosed at first-level assessment. All patients were submitted to endoscopic retrograde cholangiopancreatography to exclude biliopancreatic malformations and tested for CF by a sweat chloride test. Most patients also were studied for the research of CFTR, PRSS1, and SPINK1 gene mutations. RESULTS: : A high percentage of family history for chronic pancreatitis was observed (20.5%). The sweat test identified 8 subjects (10.3%) with classic CF (2 patients) or at risk for CF (6 patients). Genetic analysis showed mutations in CFTR, SPINK1, and PRSS1 genes in 39.6%, 7.1%, and 4.5% of patients, respectively. A biliopancreatic malformation was diagnosed in 15 patients (19.2%). We also observed biliary lithiasis (5 patients [6.5%]), congenital pancreatic polycystosis (2 patients), a case of dyslipidemia, and 1 patient with a posttransplantation, drug-induced pancreatitis. CONCLUSIONS: : Recurrent pancreatitis in children has several etiologies. Genetic testing confirms the high frequency of CFTR mutations. This suggests that it is of some value to identify patients with late-onset CF and CFTR-related disorders. |
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Authors:
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Vincenzina Lucidi; Federico Alghisi; Luigi Dall'oglio; Maria Rosaria D'Apice; Lidia Monti; Paola De Angelis; Stefano Gambardella; Adriano Angioni; Giuseppe Novelli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pancreas Volume: 40 ISSN: 1536-4828 ISO Abbreviation: Pancreas Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States |
Other Details:
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Languages: eng Pagination: 517-21 Citation Subset: IM |
Affiliation:
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From the *Unit of Cystic Fibrosis, and †Surgical and Endoscopic Digestive Unit, Bambino Gesù Children's Hospital, Istituto di Ricerca e Cura a Carattere Scientifico; ‡Department of Biopathology and Diagnostic Imaging, Tor Vergata University; §Department of Radiology, and ∥Laboratory of Cytogenetics and Molecular Genetics, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. |
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