Document Detail


The estrous cycle modulates small leucine-rich proteoglycans expression in mouse uterine tissues.
MedLine Citation:
PMID:  18951514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the pregnant mouse uterus, small leucine-rich proteoglycans (SLRPs) are drastically remodeled within a few hours after fertilization, suggesting that ovarian hormone levels modulate their synthesis and degradation. In this study, we followed by immunoperoxidase approach, the presence of four members of the SLRP family (decorin, lumican, biglycan, and fibromodulin) in the uterine tissues along the estrous cycle of the mouse. All molecules except fibromodulin, which predominates in the myometrium, showed a striking modulation in their distribution in the endometrial stroma, following the rise in the level of estrogen. Moreover, notable differences in the distribution of SLRPs were observed between superficial and deep stroma, as well as between the internal and external layers of the myometrium. Only biglycan and fibromodulin were expressed in the luminal and glandular epithelia. All four SLRPs were found in cytoplasmic granules of mononucleated cells. The pattern of distribution of the immunoreaction for these molecules in the uterine tissues was found to be estrous cycle-stage dependent, suggesting that these molecules undergo ovarian hormonal control and probably participate in the preparation of the uterus for decidualization and embryo implantation. In addition, this and previous results from our laboratory suggest the existence of two subpopulations of endometrial fibroblasts that may be related to the centrifugal development of the decidua. Anat Rec, 2008. (c) 2008 Wiley-Liss, Inc.
Authors:
Renato M Salgado; Rodolfo R Favaro; Sebastian San Martin; Telma M T Zorn
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anatomical record (Hoboken, N.J. : 2007)     Volume:  292     ISSN:  1932-8494     ISO Abbreviation:  Anat Rec (Hoboken)     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-13     Completed Date:  2009-11-09     Revised Date:  2009-12-16    
Medline Journal Info:
Nlm Unique ID:  101292775     Medline TA:  Anat Rec (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  138-53     Citation Subset:  IM    
Affiliation:
Laboratory of Reproductive and Extracellular Matrix Biology, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Estrous Cycle / metabolism*
Female
Gene Expression Regulation / physiology
Leucine / biosynthesis,  metabolism*
Mice
Pregnancy
Pregnancy, Animal / metabolism*
Proteoglycans / biosynthesis,  metabolism*
Uterus / cytology,  metabolism*
Chemical
Reg. No./Substance:
0/Proteoglycans; 61-90-5/Leucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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