Document Detail

The estrogen paradox in pulmonary arterial hypertension.
MedLine Citation:
PMID:  20656892     Owner:  NLM     Status:  MEDLINE    
Idiopathic pulmonary arterial hypertension (PAH) is a disabling condition characterized by PA vasoconstriction and remodeling as well as in situ thrombosis and eventual right heart failure. Idiopathic PAH occurs more frequently in females than in males. The female:male ratio is 1.64 ∼ 3.88:1. Although endogenous sex hormones including estrogen have been suggested to account for the observed gender differences in PAH, a precise pathobiology for the gender differences remains uncertain. Recent studies demonstrated that estrogen exerts beneficial effects on the pulmonary vasculature. However, it seems to contradict the female predominance that is observed in idiopathic PAH. Moreover, Sweeney and Voelkel (Sweeney L and Voelkel NF. Eur J Med Res 14: 433-442, 2009) showed that early and long-term estrogen exposure might be correlated with an increased risk of the development of PAH. Here we ask the question: Is estrogen a friend or a foe? According to accumulating evidence, we postulate that the different effects of estrogens on different target cells could account for this paradox, i.e., estrogens may exert beneficial effects only on the increased muscularization of vessel walls, but not on phenotypically altered endothelial cells. The effects of estrogens on the pulmonary vasculature are potent and complex, yet not fully understood. A better mechanistic understanding may allow for future therapeutic interventions in patients with PAH.
Seiichiro Sakao; Nobuhiro Tanabe; Koichiro Tatsumi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication     Date:  2010-07-23
Journal Detail:
Title:  American journal of physiology. Lung cellular and molecular physiology     Volume:  299     ISSN:  1522-1504     ISO Abbreviation:  Am. J. Physiol. Lung Cell Mol. Physiol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-30     Completed Date:  2010-10-19     Revised Date:  2011-04-11    
Medline Journal Info:
Nlm Unique ID:  100901229     Medline TA:  Am J Physiol Lung Cell Mol Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  L435-8     Citation Subset:  IM    
Dept. of Respirology, Chiba Univ., Inohana, Chuo-ku, Japan.
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MeSH Terms
Estrogens / physiology*
Hypertension, Pulmonary / physiopathology*
Muscle, Smooth, Vascular / physiopathology*
Pulmonary Artery / physiopathology*
Reg. No./Substance:
Retraction In:
Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L508   [PMID:  21368022 ]

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