Document Detail


On estimating the number density of random scatterers from backscattered acoustic signals.
MedLine Citation:
PMID:  3062865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When an acoustic pulse interacts with an inhomogeneous, attenuating medium, the backscattered signals exhibit random fluctuations which are correlated with the physical properties of the medium. This paper proposes a robust model for characterizing the statistical nature of these backscattered signals. This model takes into account frequency-dependent attenuation, spatially varying media statistics, arbitrary beam geometries, and arbitrary pulse shapes. Based on this model, statistical estimation schemes are proposed for estimating both the attenuation coefficient and scatterer number density of the medium. Using appropriate simplifying assumptions, it is shown that this model is consistent with attenuation estimation algorithms currently used for ultrasonic tissue characterization. A statistical approach for estimating the number density of scatterers is described and its theoretical performance is evaluated. The algorithm for estimating the scatterer number density incorporates measurements of both the statistical moments of the backscattered signals and the point spread function of the acoustic system. The number density algorithm has been applied to simulated waveforms, waveforms obtained from ultrasonic phantoms with known number densities, and in vitro mammalian tissues. There is an excellent agreement between theoretical, simulation, and experimental results. The application of this technique to ultrasonic tissue characterization is also discussed.
Authors:
G E Sleefe; P P Lele
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  14     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  1988  
Date Detail:
Created Date:  1989-02-21     Completed Date:  1989-02-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  709-27     Citation Subset:  IM    
Affiliation:
Laboratory for Medical Ultrasonics, Massachusetts Institute of Technology, Cambridge 02139.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Cattle
Computer Simulation
Gels
Liver / anatomy & histology
Mathematics
Models, Biological*
Models, Structural
Muscles / anatomy & histology
Scattering, Radiation*
Stochastic Processes
Swine
Ultrasonics
Ultrasonography*
Grant Support
ID/Acronym/Agency:
NCI-CA31303/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Gels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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