Document Detail


The establishment of regional identity in the Xenopus blastula.
MedLine Citation:
PMID:  2776519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The molecules involved in the commitment of Xenopus cells to particular germ layers are unknown. The question has been investigated for the cells of the blastula in in vivo cell transplantation assays and in vitro aggregation assays. Using the former technique, we have shown that vegetal cells become committed before gastrulation, even when placed in inappropriate sites. We could find no evidence of regional determination within the endoderm germ layer at the early gastrula stage. In aggregation assays, animal and vegetal cells sorted incompletely at the mid-blastula stage and more efficiently at the gastrula stage. Their behaviour may be mediated by differential expression of adhesion molecules, which so far remain unidentified.
Authors:
J Heasman; A Snape; A Turner; C C Wylie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  144     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1989  
Date Detail:
Created Date:  1989-10-17     Completed Date:  1989-10-17     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  99-109; discussion 109-12, 150-5     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of Cambridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blastocyst / cytology*
Cell Aggregation
Endoderm / cytology
Gastrula / cytology
Morphogenesis
Xenopus / embryology*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust

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