Document Detail


[The establishment of the Marfan syndrome biobank in Hungary].
MedLine Citation:
PMID:  22330841     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Collection of data from biological samples, clinical parameters, and lifestyle factors in Hungarian patients with Marfan syndrome.
METHODS: In terms of the criteria used for selection, those cases were chosen where the disorder could be clearly diagnosed on the basis of the patients' cardiovascular and systemic symptoms, as well as of their family history, in line with the guidelines set by the Revised Ghent Nosology.
RESULTS: For the purposes of developing the biobank used for the research, 102 cases were selected from the Marfan Register (cDNA from 55 patients, genomic DNA and serum from 102 patients). In addition to the samples, data have been obtained by using internationally validated surveys to further examine the role of physical activity, nutrition and various psychological factors.
CONCLUSIONS: The establishment of the Marfan Biobank enables scientists to effectively carry out research based on genetic, gene-expression and protein analysis. The biobank also provides new opportunities to study Hungarian patients with Marfan syndrome.
Authors:
Annamária Agota; Bence Agg; Kálmán Benke; József Gábor Joó; Zoltán Langmár; Krisztina Marosi; Zsuzsanna Lelovics; Zsuzsanna Lelelovics; Kitti Deé; Péter Nagy; Bernadett Köles; Endre Horváth; Zsuzsanna Crespo; Zoltán Szabolcs; Zsolt B Nagy
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Orvosi hetilap     Volume:  153     ISSN:  0030-6002     ISO Abbreviation:  Orv Hetil     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-14     Completed Date:  2012-03-20     Revised Date:  2012-04-30    
Medline Journal Info:
Nlm Unique ID:  0376412     Medline TA:  Orv Hetil     Country:  Hungary    
Other Details:
Languages:  hun     Pagination:  296-302     Citation Subset:  IM    
Affiliation:
NAGY GÉN Diagnosztikai és Kutatási Kft. Budapest. langmarzoltan@hotmail.com
Vernacular Title:
Marfan-szindróma biobankjának létrehozása.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
DNA
Female
Humans
Hungary
Kaplan-Meier Estimate
Life Style
Male
Marfan Syndrome* / diagnosis,  genetics,  mortality,  physiopathology,  psychology
Middle Aged
Motor Activity
Mouth Mucosa
Nutritional Status
Patient Selection
Questionnaires
RNA
Registries*
Tissue Banks*
Chemical
Reg. No./Substance:
63231-63-0/RNA; 9007-49-2/DNA
Comments/Corrections
Erratum In:
Orv Hetil. 2012 Apr 15;153(15):600
Note: Lelelovics, Zsuzsanna [corrected to Lelovics, Zsuzsanna]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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