Document Detail

The essential trace elements.
MedLine Citation:
PMID:  7022654     Owner:  NLM     Status:  MEDLINE    
Essential trace elements are required by man in amounts ranging from 50 micrograms to 18 milligrams per day. Acting as catalytic or structural components of larger molecules, they have specific functions and are indispensable for life. Research during the past quarter of a century has identified as essential six trace elements whose functions were previously unknown. In addition to the long-known deficiencies of iron and iodine, signs of deficiency for chromium, copper, zinc, and selenium have been identified in free-living populations. Four trace elements were proved to be essential for two or more animal species during the past decade alone. Marginal or severe trace element imbalances can be considered risk factors for several diseases of public health importance, but proof of cause and effect relationships will depend on a more complete understanding of basic mechanisms of action and on better analytical procedures and functional tests to determine marginal trace element status in man.
W Mertz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  213     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2007-03-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1332-8     Citation Subset:  IM    
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MeSH Terms
Biological Transport
Carrier Proteins / physiology
Intestinal Absorption
Trace Elements / deficiency,  physiology*
Reg. No./Substance:
0/Carrier Proteins; 0/Trace Elements

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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