| The essence of senescence. | |
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MedLine Citation:
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PMID: 21078816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Almost half a century after the first reports describing the limited replicative potential of primary cells in culture, there is now overwhelming evidence for the existence of "cellular senescence" in vivo. It is being recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting alongside cell death programs. Here, we review the various features of cellular senescence and discuss their contribution to tumor suppression. Additionally, we highlight the power and limitations of the biomarkers currently used to identify senescent cells in vitro and in vivo. |
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Authors:
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Thomas Kuilman; Chrysiis Michaloglou; Wolter J Mooi; Daniel S Peeper |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Genes & development Volume: 24 ISSN: 1549-5477 ISO Abbreviation: Genes Dev. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-16 Completed Date: 2010-12-02 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 8711660 Medline TA: Genes Dev Country: United States |
Other Details:
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Languages: eng Pagination: 2463-79 Citation Subset: IM |
Affiliation:
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Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / analysis Cell Aging / physiology* Cells / cytology Humans Neoplasms / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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