Document Detail


The essence of senescence.
MedLine Citation:
PMID:  21078816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Almost half a century after the first reports describing the limited replicative potential of primary cells in culture, there is now overwhelming evidence for the existence of "cellular senescence" in vivo. It is being recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting alongside cell death programs. Here, we review the various features of cellular senescence and discuss their contribution to tumor suppression. Additionally, we highlight the power and limitations of the biomarkers currently used to identify senescent cells in vitro and in vivo.
Authors:
Thomas Kuilman; Chrysiis Michaloglou; Wolter J Mooi; Daniel S Peeper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Genes & development     Volume:  24     ISSN:  1549-5477     ISO Abbreviation:  Genes Dev.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-16     Completed Date:  2010-12-02     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2463-79     Citation Subset:  IM    
Affiliation:
Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / analysis
Cell Aging / physiology*
Cells / cytology
Humans
Neoplasms / physiopathology
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections

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