| An eserine-like action of chloral hydrate. | |
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MedLine Citation:
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PMID: 13873598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intra-arterial injection of chloral hydrate potentiated the transmission of nerve impulses through the cat superior cervical ganglion, antagonized the ganglionblocking action of hexamethonium, and greatly enhanced the ganglion-stimulant action of acetylcholine. Effects on the ganglion-stimulant actions of carbachol, nicotine, tetramethylammonium and potassium chloride were slight or absent. Chloral hydrate itself usually had no direct stimulant action. The neuromuscular-blocking action of tubocurarine on the isolated rat diaphragm preparation was completely and rapidly reversed by chloral hydrate. This reversal was prevented by previoustreatment of the muscle with neostigmine. Chloral hydrate potentiated the actions of acetylcholine and nicotine on the isolated rabbit duodenum, and, in concentrations exceeding 1 mg/ml., produced a spasm which was abolished by hyoscine but not by mepyramine. It was concluded that these eserine-like effects were manifestations of an anticholinesterase action of chloral hydrate. Neither chloralose nor trichlorethanol showed evidence of this property. |
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Authors:
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D A BROWN |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of pharmacology and chemotherapy Volume: 19 ISSN: 0366-0826 ISO Abbreviation: Br J Pharmacol Chemother Publication Date: 1962 Aug |
Date Detail:
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Created Date: 1962-12-01 Completed Date: 1998-11-01 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0154627 Medline TA: Br J Pharmacol Chemother Country: Not Available |
Other Details:
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Languages: eng Pagination: 111-9 Citation Subset: OM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chloral Hydrate
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pharmacology* Cholinesterase Inhibitors* Physostigmine / analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 302-17-0/Chloral Hydrate; 57-47-6/Physostigmine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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