Document Detail

Is the erythrocyte sodium pump altered in human obesity?
MedLine Citation:
PMID:  6300177     Owner:  NLM     Status:  MEDLINE    
Ouabain binding and electrolyte concentrations of erythrocytes, and Na+, K+-ATPase activity of red cell ghosts were measured in normal and obese subjects, ranging from 88-257% of their ideal body weight. All three independent measurements were virtually the same in obese and nonobese groups, and no correlations were found between these three variables and the percentage of ideal body weight. These results differ from previous reports of either increased or decreased sodium pump function and suggest that Na+, K+-ATPase does not directly influence human obesity.
B M Simat; R R Mayrand; A H From; J E Morley; C Billington; D S Fullerton; K Ahmed
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  56     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  925-9     Citation Subset:  AIM; IM    
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MeSH Terms
Erythrocyte Membrane / enzymology
Erythrocytes / metabolism*
Ion Channels / metabolism*
Middle Aged
Obesity / blood*
Ouabain / blood
Potassium / blood
Sodium / blood*
Sodium-Potassium-Exchanging ATPase / blood
Grant Support
Reg. No./Substance:
0/Ion Channels; 630-60-4/Ouabain; 7440-09-7/Potassium; 7440-23-5/Sodium; EC ATPase

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