Document Detail

An equation to predict the changes in peak left ventricular pressure in hypertrophic obstructive cardiomyopathy after treatment: application to the administration of disopyramide.
MedLine Citation:
PMID:  10651183     Owner:  NLM     Status:  MEDLINE    
A theoretical equation was derived based on the time-varying elastance model to predict theoretically the relationship between the delay in the onset of left ventricular outflow obstruction and the reduction in peak left ventricular pressure (LVP) caused by treatment in hypertrophic obstructive cardiomyopathy (HOCM). ECG, LVP, and other hemodynamic parameters were measured during catheterization at a constant heart rate with atrial pacing in 16 patients with HOCM before and after intravenous administration of disopyramide (1 mg/kg). After disopyramide administration, the duration between the R wave of the ECG and the onset of obstruction (T1) was prolonged significantly (from 117 +/- 30 to 155 +/- 32 ms, P < 0.0001), and peak LVP was reduced significantly (from 222 +/- 42 to 177 +/- 39 mmHg, P < 0.0001). The relation between the prolongation of T1 and the percent reduction in peak LVP was predicted well by the theoretical equation (coefficient of determination R2 = 0.926). Our model simplifies the therapeutic strategy for reducing the left ventricular outflow pressure gradient in patients with HOCM, which is to delay the time of onset of obstruction by some methods.
K Niki; M Sugawara; S Tanino; K Iwade; S Hosoda; H Kasanuki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Heart and vessels     Volume:  14     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1999  
Date Detail:
Created Date:  2000-02-08     Completed Date:  2000-02-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  72-81     Citation Subset:  IM    
Department of Cardiovascular Sciences, The Heart Institute of Japan, Tokyo Women's Medical University School of Medicine.
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MeSH Terms
Anti-Arrhythmia Agents / administration & dosage*,  pharmacology
Cardiomyopathy, Hypertrophic / drug therapy*,  physiopathology
Disopyramide / administration & dosage*,  pharmacology
Heart Catheterization
Middle Aged
Models, Cardiovascular
Regression Analysis
Time Factors
Ventricular Function, Left / drug effects*
Ventricular Outflow Obstruction / drug therapy*,  physiopathology
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 3737-09-5/Disopyramide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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