| The epithelial-mesenchymal transition (EMT) phenomenon. | |
| | |
MedLine Citation:
|
PMID: 20943648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The epithelial-mesenchymal transition (EMT) describes a rapid and often reversible modulation of phenotype by epithelial cells. EMT was originally defined in the context of developmental stages, including heart morphogenesis, mesoderm and neural crest formation. Epithelial cells loosen cell-cell adhesion structures throughout EMT. They modulate their polarity, cytoskeleton organization and typically express vimentin filaments and downregulate cytokeratins. They become isolated, mobile and resistant to anoikis. The EMT at least superficially resembles the evolution from normal to transformed cell phenotype during carcinoma progression. The relevance of the concept of EMT in this context was indicated by in vitro models using transformed epithelial cells. Transduction pathways typical of embryogenic EMT in vivo were also found to be activated during cancer progression. More recently, it has been found that such pathways indicate an increased plasticity linked to cellular stemness and ability to generate tumors. However, in the absence of direct evidence, a number of oncologists and pathologists remain skeptical about applying the EMT concept to human tumor progression. Typically in the cancer field, EMT concept appears to be fully relevant in some situations, but the concept has to be adjusted in other situations to reflect tumor cell renewal and plasticity during carcinoma progression and metastasis. |
| | |
Authors:
|
P Savagner |
Related Documents
:
|
12573658 - Morphometric analysis of fibre cell growth in the developing chicken lens. 11381048 - Tgf-beta receptor types i and ii are differentially expressed during corneal epithelial... 3368918 - In vitro evidence of cellular adaptation to ozone toxicity in the rat trachea. 20724448 - The ubiquitin proteasome system is required for cell proliferation of the lens epitheli... 20555408 - Bidirectional communication between oocytes and follicle cells: ensuring oocyte develop... 8248208 - Altered regulation of g1 cyclins in senescent human diploid fibroblasts: accumulation o... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Volume: 21 Suppl 7 ISSN: 1569-8041 ISO Abbreviation: Ann. Oncol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-14 Completed Date: 2011-10-17 Revised Date: 2013-03-13 |
Medline Journal Info:
|
Nlm Unique ID: 9007735 Medline TA: Ann Oncol Country: England |
Other Details:
|
Languages: eng Pagination: vii89-92 Citation Subset: IM |
Affiliation:
|
IRCM U896 INSERM, CRLC Val d'Aurelle-Paul Lamarque, Montpellier, France. psavagner@valdorel.fnclcc.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Dedifferentiation / physiology Epithelial-Mesenchymal Transition / physiology* Female Humans Mammary Neoplasms, Experimental / pathology Mice Neoplasms / etiology*, pathology |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Merkel cell carcinoma.
Next Document: Cancer stem cells.