| The epidermal growth factor-like domain of the human cartilage large aggregating proteoglycan, aggrecan: increased serum concentration in rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 8162456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The large aggregating proteoglycan from human cartilage, aggrecan, has recently been shown to possess an immunologically detectable domain with close homology to epidermal growth factor (EGF), that is variably expressed by alternative mRNA splicing. Using a competitive ELISA we detected this domain in sera from both patients with RA and normal controls. The EGF-like domain could only be detected after digestion of sera with chondroitinase ABC, which demonstrates its proteoglycan origin. The concentration of the aggrecan EGF-like domain was considerably elevated in sera from patients with RA as compared to the control sera (P < 0.001), and the concentration of the domain increased with age in both the patient (r = 0.58, P < 0.05) and the control (r = 0.66, P < 0.01) group. These results demonstrate that the EGF-like domain of aggrecan could be of value as a marker of RA. |
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Authors:
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H J Møller; T Ingemann-Hansen; J H Poulsen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of rheumatology Volume: 33 ISSN: 0263-7103 ISO Abbreviation: Br. J. Rheumatol. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-05-26 Completed Date: 1994-05-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302415 Medline TA: Br J Rheumatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 44-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Chemistry, K. H. University Hospital, Aarhus C, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aggrecans Arthritis, Rheumatoid / blood*, diagnosis Biological Markers / analysis, blood Cartilage / chemistry* Chondroitin Lyases / pharmacology Enzyme-Linked Immunosorbent Assay Epidermal Growth Factor / analysis*, blood* Extracellular Matrix Proteins* Female Humans Keratan Sulfate / blood Lectins, C-Type Male Middle Aged Proteochondroitin Sulfates / analysis*, chemistry Proteoglycans / analysis*, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Aggrecans; 0/Biological Markers; 0/Extracellular Matrix Proteins; 0/Lectins, C-Type; 0/Proteochondroitin Sulfates; 0/Proteoglycans; 62229-50-9/Epidermal Growth Factor; 9056-36-4/Keratan Sulfate; EC 4.2.2.-/Chondroitin Lyases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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