Document Detail

The epidemiology of uric acid and fructose.
MedLine Citation:
PMID:  22000647     Owner:  NLM     Status:  MEDLINE    
During the past few decades, the mean serum uric acid levels and the prevalence of hyperuricemia in the general population appear to have increased. Correspondingly, the prevalence and incidence of gout have doubled. Potential reasons behind these trends include the increasing prevalence of obesity and metabolic syndrome, Western lifestyle factors, increased prevalence of medical conditions (eg, renal conditions, hypertension, and cardiovascular disorders), and use of medications that increase uric acid levels (eg, diuretics and low-dose aspirin). The substantial increase in sugar-sweetened soft drinks and associated fructose consumption also has coincided with the secular trend of hyperuricemia and gout. Recently, several large-scale epidemiologic studies have clarified a number of these long-suspected risk factors in relation with hyperuricemia and gout. Furthermore, recent studies have illuminated the substantial comorbidities of hyperuricemia and gout, particularly metabolic-cardiovascular-renal conditions. Although many prospective studies have suggested an independent association between serum uric acid levels and the future risk of cardiovascular-metabolic morbidities and mortality, only a limited number of randomized clinical trials and observational studies recently have shown that the use of allopurinol can be beneficial against these outcomes. Because these data are scarce and the effects of allopurinol might not be limited to decreasing serum uric acid levels, the potential causal role of uric acid on these outcomes remains to be clarified with further studies.
Young Hee Rho; Yanyan Zhu; Hyon K Choi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in nephrology     Volume:  31     ISSN:  1558-4488     ISO Abbreviation:  Semin. Nephrol.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-17     Completed Date:  2012-03-19     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8110298     Medline TA:  Semin Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  410-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Aged, 80 and over
Diabetes Mellitus / etiology
Fructose / adverse effects*
Gout / epidemiology*,  etiology*
Hyperuricemia / complications,  epidemiology*,  etiology*
Metabolic Syndrome X / etiology
Middle Aged
Obesity / etiology
Risk Factors
Uric Acid / blood*
Young Adult
Grant Support
R01 AR056291/AR/NIAMS NIH HHS; R01 AR056291-04/AR/NIAMS NIH HHS; R21 AR056042/AR/NIAMS NIH HHS; R21 AR056042-02/AR/NIAMS NIH HHS
Reg. No./Substance:
268B43MJ25/Uric Acid; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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