Document Detail

The epidemiology of sudden infant death syndrome.
MedLine Citation:
PMID:  12495955     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Twins compared to singletons are at increased risk of sudden infant death syndrome (SIDS). AIMS: To compare the epidemiology of SIDS in twins and singletons and to test the hypothesis that monozygous (MZ) were at greater risk of SIDS than dizygous (DZ) twins. METHODS: Data from the Office for National Statistics on all registered live births and infant deaths with registered cause of death "sudden unexpected death in infancy" in England and Wales from 1993 to 1998 were obtained, together with the registered birth weight and, for twins, whether they were of like or unlike sex. RESULTS: The crude relative risk of SIDS in twins is twice that in singletons. There has been a significant temporal decline in SIDS mortality. There is also a significant increase in risk with decreasing birth weight for both twins and singletons. The birth weight specific risk of SIDS in all except for those > or =3000 g is greater in singletons than in twins. There is no significant difference in risk of SIDS in like compared with unlike sex twins. CONCLUSIONS: In spite of a lower risk of SIDS in twins compared with singletons for each birth weight group <3000 g, one component of the higher crude relative risk of SIDS in twins is attributable to the higher proportion of twins that are of low birth weight. A second component is the higher risk in twins compared with singletons for those of birth weight > or =3000 g. Like sex are at no greater risk than unlike sex twins, which suggests that zygosity is not a significant factor in SIDS.
M J Platt; P O Pharoah
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  88     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-23     Completed Date:  2003-01-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-9     Citation Subset:  AIM; IM    
FSID Unit of Perinatal and Paediatic Epidemiology, Department of Public Health, Muspratt Laboratory, Liverpool L69 3GB, UK.
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MeSH Terms
Chi-Square Distribution
Diseases in Twins / epidemiology*
England / epidemiology
Infant, Low Birth Weight
Infant, Newborn
Sex Distribution
Sudden Infant Death / epidemiology*
Twins, Monozygotic
Wales / epidemiology
Comment In:
Arch Dis Child. 2003 May;88(5):460-1   [PMID:  12716730 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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