| The epidemiology of motor neuron disease in Northern Ireland using capture-recapture methodology. | |
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MedLine Citation:
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PMID: 20550486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Capture-recapture analysis allows an investigator to estimate the number of unobserved cases in an epidemiological survey, although it has not been employed widely in published research to date. This study examines the usefulness of capture-recapture analysis in measuring the incidence and prevalence of motor neuron disease (MND) in Northern Ireland (NI). Cases were ascertained from the NI MND register to measure incidence and prevalence. The authors then employed capture-recapture analysis to estimate the number of missing cases. Less than one case was estimated to be missing from the prevalence study, providing a completeness of ascertainment of 99%. Prevalence was 3.3 per 100,000 population adjusted to the European standard population and was unchanged when adjusted for missing cases. Incidence was 1.4 per 100,000 person-years adjusted to the European standard population. Due to the lack of overlapping sources it was inferred that there were no missing cases and completeness of ascertainment was estimated at 100%. In conclusion, capture-recapture analysis is relatively simple to perform and provides an objective measure of case ascertainment in epidemiological studies. The authors feel that future investigators should consider employing capture-recapture methods, where possible, to validate their estimations of disease frequency in MND. |
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Authors:
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Colette Donaghy; Judith Clarke; Chris Patterson; Frank Kee; Orla Hardiman; Victor Patterson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases Volume: 11 ISSN: 1471-180X ISO Abbreviation: Amyotroph Lateral Scler Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-06-16 Completed Date: 2010-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101283386 Medline TA: Amyotroph Lateral Scler Country: England |
Other Details:
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Languages: eng Pagination: 374-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, Royal Victoria Hospital, Belfast, Northern Ireland. donaghy1a@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cohort Studies Cross-Sectional Studies Data Collection / methods* Female Humans Male Motor Neuron Disease / epidemiology* Northern Ireland / epidemiology Prevalence Retrospective Studies |
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