Document Detail

The epidemiology of methicillin-susceptible and methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit, 2000-2007.
MedLine Citation:
PMID:  19710681     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) infections in a neonatal intensive care unit (NICU).
STUDY DESIGN: A retrospective chart review was conducted from 2000-2007; demographic and clinical characteristics of infected infants and crude mortality were assessed.
RESULTS: During the study period, there were 123 infections caused by MSSA and 49 infections caused by MRSA. Although the types of infections caused by MSSA and MRSA were similar, infants with MRSA infections were younger at clinical presentation than infants with MSSA infections (P=0.03). The overall rate of S. aureus infections was approximately 15-30 per 1000 patient-admissions. The rate of bacteremia and skin and soft tissue infections remained stable over time. Among extremely low birth weight infants (birth weight <1000 g), 4.8 and 1.8% developed an infection caused by MSSA or MRSA, respectively. Infections occurred in a bimodal distribution of birth weight; 53% of infections occurred in extremely low birth weight infants and 27% occurred among term infants birth weight >or=2500 g, many of whom underwent surgical procedures.
CONCLUSIONS: MSSA and MRSA remain significant pathogens in the NICU, particularly for extremely premature infants and term infants undergoing surgery. Further work should investigate infection control strategies that effectively target the highest risk groups and determine if vertical transmission of MRSA is responsible for the younger age at presentation of infection.
A J Carey; J Duchon; P Della-Latta; L Saiman
Publication Detail:
Type:  Journal Article     Date:  2009-08-27
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  30     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-06-07     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-9     Citation Subset:  IM    
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MeSH Terms
Gestational Age
Hospitals, Pediatric / statistics & numerical data
Hospitals, University / statistics & numerical data
Infant, Extremely Low Birth Weight
Infant, Newborn
Intensive Care Units, Neonatal / statistics & numerical data*
Methicillin-Resistant Staphylococcus aureus*
Microbial Sensitivity Tests
Population Surveillance*
Retrospective Studies
Risk Factors
Staphylococcal Infections / epidemiology*
Staphylococcus aureus / drug effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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