Document Detail

The epidemiology of cardiovascular defects, part 2: a study based on data from three large registries of congenital malformations.
MedLine Citation:
PMID:  12632214     Owner:  NLM     Status:  MEDLINE    
There were three objectives of this study: to investigate possible specificity in the association between specific cardiac defects and chromosomal anomalies; to evaluate ways of categorizing cardiac defects into larger groups with epidemiological similarities that could indicate similarities in etiology or pathogenesis; and to analyze the relationship between specific cardiac defects and diabetes. We pooled data on infants (aged 1 year or younger) with congenital cardiovascular defects from three large birth defect registries in California, Sweden, and France. The registries in Sweden and France obtained data through reporting from various sources; in California, medical records were reviewed. For severe congenital heart defects, the percentage of infants with identified chromosomal anomalies varied between 0.9% for d-TGV to 68.4% for ECD. In general, specific cardiac conditions have different risk factors. For example, conotruncal defects have been traditionally grouped, but the data presented in this paper indicates more differences for risk factors for the components of conotruncal defects: tetralogy of Fallot, d-TGV, common truncus, and DORV. In general, we suggest the strategy of "splitting" rather than "lumping" when searching for specific genetic factors and/or teratogens. Adequate analysis thus requires large registries or collaboration among registries. The findings did not support constellations between mothers' diabetes and specific defects.
J A Harris; C Francannet; P Pradat; E Robert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-03-17
Journal Detail:
Title:  Pediatric cardiology     Volume:  24     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-06-05     Completed Date:  2003-11-12     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  222-35     Citation Subset:  IM    
California Birth Defects Monitoring Program, California Department of Health Services, 1830 Embarcadero, Suite 100, Oakland, CA, 94606 USA.
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MeSH Terms
Abnormalities, Drug-Induced / etiology*
Anticonvulsants / adverse effects*
California / epidemiology
Chromosome Aberrations / statistics & numerical data*
France / epidemiology
Heart Defects, Congenital / chemically induced,  epidemiology*,  etiology,  genetics*
Infant, Newborn
Lithium Compounds / adverse effects*
Pregnancy in Diabetics / complications*
Registries / statistics & numerical data*
Sweden / epidemiology
Reg. No./Substance:
0/Anticonvulsants; 0/Lithium Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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