Document Detail

An epidemiological study of RSV infection in the Gambia.
MedLine Citation:
PMID:  12163920     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe the epidemiology of respiratory syncytial virus (RSV) infection in a developing country. METHODS: The work was carried out in three hospitals for primary cases and in the community for secondary cases in the western region of the Gambia, West Africa. RSV infection was diagnosed by immunofluorescence of nasopharyngeal aspirate samples in children younger than two years admitted to hospital with acute lower respiratory infection (ALRI). Routine records of all children with ALRI were analysed, and the incidence rates of ALRI, severe RSV-associated respiratory illness and hypoxaemic RSV infections were compared. A community-based study was undertaken to identify secondary cases and to obtain information about spread of the virus. FINDINGS: 4799 children with ALRI who were younger than two years and lived in the study area were admitted to the study hospitals: 421 had severe RSV-associated respiratory illness; 55 of these were hypoxaemic. Between 1994 and 1996, the observed incidence rate for ALRI in 100 children younger than one year living close to hospital was 9.6 cases per year; for severe RSV-associated respiratory illness 0.83; and for hypoxaemic RSV-associated respiratory illness 0.089. The proportion of all ALRI admissions due to RSV was 19%. Overall, 41% of children younger than five years in compounds in which cases lived and 42% in control compounds had evidence of RSV infection during the surveillance period. CONCLUSION: RSV is an important cause of ALRI leading to hospital admission in the Gambia. Morbidity is considerable and efforts at prevention are worthwhile.
Martin W Weber; Paul Milligan; Mariama Sanneh; Agnes Awemoyi; Raduwan Dakour; Gisela Schneider; Ayo Palmer; Mariatou Jallow; Anslem Oparaogu; Hilton Whittle; E Kim Mulholland; Brian M Greenwood
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-07-30
Journal Detail:
Title:  Bulletin of the World Health Organization     Volume:  80     ISSN:  0042-9686     ISO Abbreviation:  Bull. World Health Organ.     Publication Date:  2002  
Date Detail:
Created Date:  2002-08-06     Completed Date:  2003-08-12     Revised Date:  2009-05-29    
Medline Journal Info:
Nlm Unique ID:  7507052     Medline TA:  Bull World Health Organ     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  562-8     Citation Subset:  IM    
Medical Research Council Laboratories, Fajara, The Gambia.
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MeSH Terms
Age Distribution
Developing Countries
Epidemiologic Studies
Fluorescent Antibody Technique
Gambia / epidemiology
Hospitals, Pediatric
Hospitals, Rural
Hospitals, Urban
Infant, Newborn
Patient Admission / statistics & numerical data
Population Surveillance
Respiratory Syncytial Virus Infections / epidemiology*,  etiology,  prevention & control
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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