Document Detail

An epidemiological analysis of retinopathy of prematurity over 10 years.
MedLine Citation:
PMID:  18524194     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To analyze the incidence of retinopathy of prematurity (ROP) in a single neonatal intensive care unit over 10 years to clarify its ROP profile and how it was modified by advances in neonatal care. METHODS: Epidemiological data related to incidence and severity of ROP were collected over 10 years. Premature infants with a birth weight of less than 1,500 g underwent a screening fundus examination and ROP was defined according to the International Classification of Retinopathy of Prematurity. The survival rates and incidence of ROP were calculated and compared for two consecutive time periods (1995-1999 vs 2000-2004), dividing the study population into subgroups according to their birth weights and gestational age. RESULTS: Data of 607 preterm infants were collected. Survival rate significantly improved in the later time period (from 76.6% to 88.6%). The incidence of total, severe, and surgical ROP did not differ overall in the two time periods despite changes in survival rate, although some changes occurred in the most immature infants over time. CONCLUSION: Increased survival of immature infants seemed to correlate with an increased risk for severe ROP and need for retinal ablation therapy, even if the incidence did not reach statistical significance.
Carmen Giannantonio; Patrizia Papacci; Fernando Molle; Domenico Lepore; Francesca Gallini; Costantino Romagnoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric ophthalmology and strabismus     Volume:  45     ISSN:  0191-3913     ISO Abbreviation:  J Pediatr Ophthalmol Strabismus     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-06-05     Completed Date:  2008-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7901143     Medline TA:  J Pediatr Ophthalmol Strabismus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  162-7     Citation Subset:  IM    
Department of Pediatrics, Division of Neonatology, Catholic University Sacred Heart, Rome, Italy.
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MeSH Terms
Birth Weight
Gestational Age
Infant, Low Birth Weight
Infant, Newborn
Intensive Care Units, Neonatal / statistics & numerical data
Italy / epidemiology
Retinopathy of Prematurity / epidemiology*
Survival Rate

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