Document Detail

An epidemiologic analysis of Mycobacterium avium complex disease in homosexual men infected with human immunodeficiency virus type 1.
MedLine Citation:
PMID:  7620006     Owner:  NLM     Status:  MEDLINE    
Cofactors associated with the Mycobacterium avium complex (MAC) disease and its prognosis in incident cases of AIDS in homosexuals were studied. We compared 51 men in whom MAC disease developed as the initial AIDS-defining illness (termed AIDS illness hereafter); 157 men who had MAC disease subsequent to another AIDS illness; and 884 men who had only non-MAC AIDS illnesses. MAC disease was the initially diagnosed AIDS illness more often in Baltimore (6.9%) and Los Angeles (5.6%) than in Chicago (2.6%) and Pittsburgh (0) (P < .01). MAC disease also was a more common subsequent AIDS illness in Baltimore (14.3%) and Los Angeles (22.4%) than in Chicago (8.5%) and Pittsburgh (6.5%) (P < .0001). Prophylaxis for Pneumocystis carinii infection increased the occurrence of MAC disease as the initial AIDS illness (from 2.3% to 12.5%; P < .0001). A low white blood cell (WBC) count was slightly more predictive of MAC disease than was a low CD4+ cell count. At 0-6, 7-12, and 13-18 months before diagnosis, the WBC cell counts of 75.0%, 61.1%, and 50.0%, respectively, of those with MAC disease as the initial AIDS illness were < or = 3,400/microL. Men in whom cytomegalovirus disease developed were at higher risk for subsequent MAC disease (relative hazard = 2.65; P < .0001). MAC disease also increased the risk for subsequent cytomegalovirus disease (relative hazard = 3.96; P < .0001).
D R Hoover; N M Graham; H Bacellar; R Murphy; B Visscher; R Anderson; J McArthur
Related Documents :
17141036 - Retinal pigment epithelium.
16029456 - Role of extracorporeal photochemotherapy in patients with refractory chronic graft-vers...
6388506 - Oral patterns of acute and chronic graft-v-host disease.
3131226 - A coded histologic study of hepatic graft-versus-host disease after human bone marrow t...
10801766 - Cell transplantation as future therapy for cardiovascular disease?: a workshop of the n...
17341996 - Renal artery stenosis and cardiovascular risk.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  20     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-08-31     Completed Date:  1995-08-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1250-8     Citation Subset:  IM; X    
Johns Hopkins School of Hygiene and Public Health, Department of Epidemiology, Baltimore, Maryland 21205, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
AIDS-Related Opportunistic Infections / epidemiology,  etiology*,  mortality
CD4 Lymphocyte Count
Ethanol / adverse effects
Homosexuality, Male*
Mycobacterium avium-intracellulare Infection / epidemiology,  etiology*,  mortality
Risk Factors
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Characteristics of and risk factors for relapse of brucellosis in humans.
Next Document:  Prognostic value of electrocardiographic monitoring of patients with severe diphtheria.