Document Detail

The eosinophil granulocyte in psoriasis.
MedLine Citation:
PMID:  2317447     Owner:  NLM     Status:  MEDLINE    
The presence of eosinophils and eosinophil cationic protein (ECP) in the involved and non-involved skin in patients with psoriasis was studied using a polyclonal antibody specific for ECP and a monoclonal antibody (EG2) specific for activated eosinophils and secreted ECP. ECP immunoreactive eosinophils were found in all the specimens from involved psoriatic skin. In new lesions in patients with rapidly progressive disease, intense ECP immunoreactivity was detected both intra- and extracellularly, particularly in the upper third of the epidermis and usually in association with granulocytes. In stable or slowly progressive lesions, less ECP was observed. The EG2-immunoreactivity was positive in the same areas. ECP was also determined in suction-blister fluid from lesional and non-involved skin in psoriasis patients and in healthy subjects. The ECP concentration was greatly elevated in the fluid from lesions in patients with more acute and progressive disease.
A Lundin; K Fredens; G Michaëlsson; P Venge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  122     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-05-07     Completed Date:  1990-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  181-93     Citation Subset:  IM    
Department of Dermatology, University Hospital, Uppsala, Sweden.
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MeSH Terms
Blood Proteins / analysis*
Eosinophil Granule Proteins
Eosinophils / metabolism*
Leukocyte Count
Middle Aged
Psoriasis / metabolism,  pathology*
Skin / metabolism,  pathology*
Reg. No./Substance:
0/Blood Proteins; 0/Eosinophil Granule Proteins; EC 3.1.-/Ribonucleases

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