Document Detail


The enzymatic and electrocardiographic changes falsely indicative of an acute myocardial infarct during hypothyroidism
MedLine Citation:
PMID:  8139781     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Estimation of the enzymes CPK and LDH, with their isoenzymes, is useful in diagnosing myocardial infarction and monitoring its progress. However, increases of CPK-MB and LDH1, may be not associated with acute myocardial infarction, as in hypothyroidism, muscular dystrophy, polymyositis, malignant disease. We report a case of hypothyroidism with increased CPK-MB and LDH1. At the beginning the diagnosis was difficult because of altered electrocardiogram associated with one event of "burning" localized altered at the anterior thorax. This case illustrates that plasma enzyme activity and isoenzyme profiles should be interpreted with caution when clinical and instrumental (eco 2D) findings are not entirely associated with myocardial infarction.
Authors:
L Minutiello
Publication Detail:
Type:  Case Reports; English Abstract; Journal Article    
Journal Detail:
Title:  Minerva cardioangiologica     Volume:  41     ISSN:  0026-4725     ISO Abbreviation:  Minerva Cardioangiol     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-04-28     Completed Date:  1994-04-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400725     Medline TA:  Minerva Cardioangiol     Country:  ITALY    
Other Details:
Languages:  ita     Pagination:  597-602     Citation Subset:  IM    
Affiliation:
Divisione di Cardiologia, Presidio Ospedaliero di Camerino, Regione Marche, USL 20, Marcerata.
Vernacular Title:
Alterazioni enzimatiche ed elettrocardiografiche falsamente indicative di infarto miocardico acuto in corso di ipotiroidismo.
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MeSH Terms
Descriptor/Qualifier:
Clinical Enzyme Tests*
Creatine Kinase / blood
Diagnosis, Differential
Echocardiography
Electrocardiography*
False Positive Reactions
Female
Humans
Hypothyroidism / diagnosis*
Isoenzymes
L-Lactate Dehydrogenase / blood
Middle Aged
Myocardial Infarction / diagnosis*
Thyroid Function Tests
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.7.3.2/Creatine Kinase

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