| An environmentally relevant endocrine-disrupting antiandrogen, vinclozolin, affects calling behavior of male Xenopus laevis. | |
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MedLine Citation:
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PMID: 20600051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vinclozolin (VIN) is an antiandrogenic model substance as well as a common fungicide that can affect the endocrine system of vertebrates. The objective of this study was to investigate how VIN affects mate calling behavior of South African clawed frogs (Xenopus laevis) and whether it is effective at environmentally relevant concentrations. Male X. laevis were injected with human chorionic gonadotropin (hCG) to stimulate their androgen-controlled mate calling behavior and were treated with VIN at concentrations of 10(-6), 10(-8) and 10(-10)M. VIN at 10(-6)M reduced calling activity. Furthermore, the vocalization composition of VIN-treated X. laevis was altered. The call types advertisement calls and chirping are uttered by reproductively active males, whereas the call types growling, ticking, and rasping indicate a sexually unaroused state of a male. VIN at any of the tested concentrations led to a decrease in utterance of calls, which indicate a sexually aroused state of the males, and an increase in relative proportions of calls, indicating a sexually unaroused state of the males. Additionally, the mean duration of clicks and the number of accentuated clicks during the advertisement calls decreased at all concentrations of VIN. No significant differences were observed in any other temporal or spectral calling parameters between the treatments. This study illustrates that exposure to the antiandrogen VIN might result in a reduced reproductive success by altering mate calling behavior of X. laevis. Moreover, it suggests that the behavioral parameters examined in this study can be used as sensitive biomarkers for detecting antiandrogenic endocrine disrupting compounds in amphibians. |
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Authors:
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Frauke Hoffmann; Werner Kloas |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-16 |
Journal Detail:
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Title: Hormones and behavior Volume: 58 ISSN: 1095-6867 ISO Abbreviation: Horm Behav Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2011-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217764 Medline TA: Horm Behav Country: United States |
Other Details:
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Languages: eng Pagination: 653-9 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Ecophysiology and Aquaculture, Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Müggelseedamm 310, Berlin, Germany. f.hoffmann@igb-berlin.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Androgen Antagonists
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pharmacology Animals Endocrine Disruptors / pharmacology* Fungicides, Industrial / pharmacology Male Oxazoles / pharmacology* Random Allocation Sexual Behavior, Animal / drug effects, physiology Social Behavior Vocalization, Animal / drug effects*, physiology Water Pollutants, Chemical / pharmacology* Xenopus laevis* / physiology |
| Chemical | |
Reg. No./Substance:
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0/Androgen Antagonists; 0/Endocrine Disruptors; 0/Fungicides, Industrial; 0/Oxazoles; 0/Water Pollutants, Chemical; 50471-44-8/vinclozolin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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