| The envelope glycoprotein of HIV-1 alters NMDA receptor function. | |
MedLine Citation:
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PMID: 7726990 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human immunodeficiency virus (HIV-1) infection often results in central nervous system (CNS) dysfunction, yet the mechanism(s) of action for HIV-1 in the CNS are not fully understood. In the present study gp120, the HIV-1 envelope glycoprotein, was shown to selectively inhibit N-methyl-D-aspartate (NMDA) receptor function. In addition to inhibiting radioligand binding to rat NMDA receptors, gp120 inhibited NMDA-induced currents in Xenopus oocytes, attenuated NMDA-stimulated calcium flux and cytotoxicity in cultured cerebellar granule cells, and provided partial protection against NMDA-induced lethality in vivo. These findings suggest that NMDA receptor complex is a possible site of action of HIV-1 within the CNS. |
Authors:
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P M Sweetnam; O H Saab; J T Wroblewski; C H Price; E W Karbon; J W Ferkany |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The European journal of neuroscience Volume: 5 ISSN: 0953-816X ISO Abbreviation: Eur. J. Neurosci. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1994-01-27 Completed Date: 1994-01-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8918110 Medline TA: Eur J Neurosci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 276-83 Citation Subset: IM; X |
Affiliation:
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NovaScreen, A Division of Nova Pharmaceutical Corporation, Baltimore, MD 21224. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Channel Blockers / pharmacology Cells, Cultured Dizocilpine Maleate / antagonists & inhibitors, metabolism Electrophysiology HIV Envelope Protein gp120 / pharmacology* N-Methylaspartate / antagonists & inhibitors, physiology, poisoning Oocytes / metabolism Phencyclidine / analogs & derivatives, antagonists & inhibitors, metabolism Pipecolic Acids / antagonists & inhibitors, metabolism Radioligand Assay Rats Receptors, N-Methyl-D-Aspartate / drug effects*, metabolism, physiology Recombinant Proteins Xenopus |
| Grant Support | |
ID/Acronym/Agency:
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NIAID NS 28130/NS/NINDS NIH HHS; NIAID U01A127221/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/HIV Envelope Protein gp120; 0/Pipecolic Acids; 0/Receptors, N-Methyl-D-Aspartate; 0/Recombinant Proteins; 110347-85-8/selfotel; 21500-98-1/1-(1-(2-thienyl)cyclohexyl)piperidine; 6384-92-5/N-Methylaspartate; 77-10-1/Phencyclidine; 77086-22-7/Dizocilpine Maleate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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