Document Detail


The envelope glycoprotein of HIV-1 alters NMDA receptor function.
MedLine Citation:
PMID:  7726990     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human immunodeficiency virus (HIV-1) infection often results in central nervous system (CNS) dysfunction, yet the mechanism(s) of action for HIV-1 in the CNS are not fully understood. In the present study gp120, the HIV-1 envelope glycoprotein, was shown to selectively inhibit N-methyl-D-aspartate (NMDA) receptor function. In addition to inhibiting radioligand binding to rat NMDA receptors, gp120 inhibited NMDA-induced currents in Xenopus oocytes, attenuated NMDA-stimulated calcium flux and cytotoxicity in cultured cerebellar granule cells, and provided partial protection against NMDA-induced lethality in vivo. These findings suggest that NMDA receptor complex is a possible site of action of HIV-1 within the CNS.
Authors:
P M Sweetnam; O H Saab; J T Wroblewski; C H Price; E W Karbon; J W Ferkany
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  5     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1994-01-27     Completed Date:  1994-01-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  276-83     Citation Subset:  IM; X    
Affiliation:
NovaScreen, A Division of Nova Pharmaceutical Corporation, Baltimore, MD 21224.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium Channel Blockers / pharmacology
Cells, Cultured
Dizocilpine Maleate / antagonists & inhibitors,  metabolism
Electrophysiology
HIV Envelope Protein gp120 / pharmacology*
N-Methylaspartate / antagonists & inhibitors,  physiology,  poisoning
Oocytes / metabolism
Phencyclidine / analogs & derivatives,  antagonists & inhibitors,  metabolism
Pipecolic Acids / antagonists & inhibitors,  metabolism
Radioligand Assay
Rats
Receptors, N-Methyl-D-Aspartate / drug effects*,  metabolism,  physiology
Recombinant Proteins
Xenopus
Grant Support
ID/Acronym/Agency:
NIAID NS 28130/NS/NINDS NIH HHS; NIAID U01A127221/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/HIV Envelope Protein gp120; 0/Pipecolic Acids; 0/Receptors, N-Methyl-D-Aspartate; 0/Recombinant Proteins; 110347-85-8/selfotel; 21500-98-1/1-(1-(2-thienyl)cyclohexyl)piperidine; 6384-92-5/N-Methylaspartate; 77-10-1/Phencyclidine; 77086-22-7/Dizocilpine Maleate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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