Document Detail

The enterochromaffin-like (ECL) cell. Physiological and pathophysiological role.
MedLine Citation:
PMID:  8323755     Owner:  NLM     Status:  MEDLINE    
Histamine has a central role in the regulation of gastric acid secretion. This histamine is produced by and released from the enterochromaffin-like (ECL) cell which accordingly has a key-regulatory role in the oxyntic mucosa. Gastrin and the vagal nerves stimulate the formation and release of histamine from the ECL cell. Moreover, gastrin and the vagal nerves also stimulate the proliferation of the ECL cell. An increased ECL cell density may partly explain the increased acid secretion in patients with duodenal ulcer, particularly in patients with Zollinger-Ellison syndrome. The reduced potency of histamine-2 blockers in patients with Zollinger-Ellison syndrome is probably due to increased histamine release by an elevated ECL cell mass. Prolonged and profound hypergastrinemia may lead to ECLomas. Moreover, a proportion of diffuse gastric carcinomas may originate from ECL cells.
H L Waldum; A K Sandvik; U Syversen; E Brenna
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  32     ISSN:  0284-186X     ISO Abbreviation:  Acta Oncol     Publication Date:  1993  
Date Detail:
Created Date:  1993-08-10     Completed Date:  1993-08-10     Revised Date:  2009-05-12    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Department of Medicine, University Hospital of Trondheim, Norway.
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MeSH Terms
Enterochromaffin Cells / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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