Document Detail


The enigmatic role of mast cells in dominant tolerance.
MedLine Citation:
PMID:  19581806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: The role of regulatory T cells (Treg) in peripheral tolerance has been studied extensively in transplantation research. Recently, mast cells have been shown to play an indispensable role in allograft tolerance. The purpose of this review is to inform the reader on the current standings of the role of mast cells in dominant tolerance with an emphasis on the interaction of mast cells with Treg.
RECENT FINDINGS: Mast cells are required to sustain peripheral tolerance via Treg. Treg can stabilize mast cells degranulation by contact-dependent mechanisms through the interaction of OX40 and its ligand OX40L, and by production of soluble factors, such as interleukin-10 and transforming growth factor-beta. Conversely, the activation and subsequent degranulation of mast cells break peripheral tolerance.
SUMMARY: Both mast cells and Treg are needed to create a local immunosuppressive environment in the transplant. Treg are not only necessary to suppress effector T-cell responses but also to stabilize mast cells. Mast cells in return could contribute to the immunosuppressive state by release of transforming growth factor-beta, interleukin-10 and specific proteases. However, the molecular basis for mast cells control of Treg suppression in organ transplantation is still unresolved.
Authors:
Victor C de Vries; Karina Pino-Lagos; Raul Elgueta; Randolph J Noelle
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in organ transplantation     Volume:  14     ISSN:  1531-7013     ISO Abbreviation:  Curr Opin Organ Transplant     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-15     Completed Date:  2009-09-24     Revised Date:  2013-12-25    
Medline Journal Info:
Nlm Unique ID:  9717388     Medline TA:  Curr Opin Organ Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  332-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Communication*
Cell Degranulation
Graft Survival*
Humans
Inflammation Mediators / metabolism
Interleukin-10 / metabolism
Mast Cells / immunology*
OX40 Ligand / metabolism
Organ Transplantation*
Receptors, OX40 / metabolism
Signal Transduction
T-Lymphocytes, Regulatory / immunology*
Transforming Growth Factor beta / metabolism
Transplantation Tolerance*
Transplantation, Homologous
Grant Support
ID/Acronym/Agency:
R21 AI084089/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Inflammation Mediators; 0/OX40 Ligand; 0/Receptors, OX40; 0/Transforming Growth Factor beta; 130068-27-8/Interleukin-10
Comments/Corrections

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