| The enigmatic role of Sir2 in aging. | |
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MedLine Citation:
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PMID: 16286003 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this issue of Cell, Longo and colleagues (Fabrizio et al., 2005) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction. |
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Authors:
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Brian K Kennedy; Erica D Smith; Matt Kaeberlein |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Cell Volume: 123 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-15 Completed Date: 2006-01-19 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 548-50 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Dehydrogenase
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metabolism Cyclic AMP-Dependent Protein Kinases / genetics, physiology Ethanol / metabolism Histone Deacetylases / genetics, physiology* Hot Temperature Models, Biological Mutation / genetics Oxidative Stress Protein Kinases / genetics, physiology Protein-Serine-Threonine Kinases Saccharomyces cerevisiae / genetics, physiology* Saccharomyces cerevisiae Proteins / genetics, physiology Silent Information Regulator Proteins, Saccharomyces cerevisiae / genetics, physiology* Sirtuin 1 Sirtuin 2 Sirtuins / genetics, physiology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Saccharomyces cerevisiae Proteins; 0/Silent Information Regulator Proteins, Saccharomyces cerevisiae; 64-17-5/Ethanol; EC 1.1.1.1/Alcohol Dehydrogenase; EC 2.7.-/Protein Kinases; EC 2.7.1.-/SCH9 protein kinase; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.1/target of rapamycin protein, S cerevisiae; EC 2.7.11.11/Cyclic AMP-Dependent Protein Kinases; EC 3.5.1.-/SIR2 protein, S cerevisiae; EC 3.5.1.-/Sirt1 protein, mouse; EC 3.5.1.-/Sirtuin 1; EC 3.5.1.-/Sirtuin 2; EC 3.5.1.-/Sirtuins; EC 3.5.1.98/Histone Deacetylases |
| Comments/Corrections | |
Comment On:
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Cell. 2005 Nov 18;123(4):655-67
[PMID:
16286010
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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